Skip to main content
Psychedex
Article

DOM Facts

Psychedelic; Substituted amphetamine; Serotonin 2A receptor agonist

Description

DOM (2,5-dimethoxy-4-methylamphetamine) — also known as STP — is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors in the brain, producing the visual and cognitive shifts of classical psychedelics.[1][2]

Subjective effects include color intensification, geometric visual patterns, time alteration, emotional enhancement, and introspective thinking.[3] The experience is more body-present and somatically energizing than tryptamine psychedelics — a slow-building, stable plateau with physical aliveness underlying the visuals.[4]

DOM does not produce physical dependence, and no lethal dose has been established in any species.[4]safety citation needed The primary danger is psychological: the exceptionally long duration creates extended exposure to altered states, and the slow onset has historically triggered dangerous redosing.[5]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 0.5 mgLight1 – 2 mgCommon3 – 5 mgStrong5 – 10 mgHeavy10+ mg

Starts in 30 – 120 minLasts 14 – 20 hoursAfter-effects 4 – 16 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
LSD; psilocybin; mescaline; DOI; DOB; DPT

Effectslikely at a common dose

Perception
Color enhancement; Color alteration; Symmetrical texture repetition; Tracers; Brightness alteration; Music enhancement; Visual drifting; Environmental patterning; Geometry; Visual breathing; Visual morphing; +20 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
Body
Pupil dilation; Wakefulness; Appetite suppression; Vasoconstriction; Stimulation; Body high; Dry mouth; Insomnia; +26 possible, including Temperature dysregulation, Excessive sweating, Muscle tension
Thinking
Pattern recognition enhancement; Conceptual thinking; Thought connectivity; Novelty enhancement; Aesthetic enhancement; Openness enhancement; +26 possible, including Memory suppression, Suggestibility enhancement, Cognitive impairment
Feeling
none likely · 8 possible, including Emotional lability, Anxiety
Self
none likely · 8 possible, including Derealization, Depersonalization
Time
Time alteration; Temporal disorientation; +2 possible
Transpersonal
none likely · 1 possible
Awareness
none likely · 4 possible

Who shouldn't take it

Absolute
Psychotic disorders; Pregnancy; Phenothiazine antipsychotic use; Concurrent tramadol use
Relative
Uncontrolled hypertension; Epilepsy; Bipolar disorder; Concurrent SSRI/SNRI use

Combinations60 recorded

Lethal (1)
MAOIs
Dangerous (26)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Ephedrine, Pseudoephedrine; GHB, GBL; Local anesthetics; MDMA, MDA; NRIs; Opioids; SSRIs; Stimulants; 5-HTP, Tryptophan; Antipsychotics; Buspirone; Caffeine; Dopamine agonists; DXM; GHB, Baclofen; Ibogaine; Ketamine, DXM, PCP; Lithium; NDRIs (Wellbutrin); NSAIDs; Psychedelics; Salvia, Ibogaine; and 2 more, see full page
Caution (29)
See full page: psychedex.org/substances/dom
Not graded (4)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Luethi D et al. (2026) The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects — Molecular Psychiatry doi:10.1038/s41380-025-03325-1
  2. [2]
    ^Li JX, Rice KC, France CP (2009) Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys: antagonism and apparent pA2 analyses. — Journal of pharmacology and experimental therapeutics doi:10.1124/jpet.108.145458
  3. [3]
    ^Shulgin A, Shulgin A (1991) PiHKAL #68: DOM Link
  4. [4]
    ^abNichols DE (2016) Psychedelics — Pharmacological Reviews doi:10.1124/pr.115.011478
  5. [5]
    ^Trout K, Daley PF (2024) The origin of 2,5-dimethoxy-4-methylamphetamine (DOM, STP) — Drug Testing and Analysis doi:10.1002/dta.3667
Print version
Report an issue