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DOET Facts

Psychedelic; Substituted amphetamine; Serotonin 2A receptor agonist

Description

DOET (2,5-dimethoxy-4-ethylamphetamine) — also known as Hecate — is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors in the brain, producing the introspective and perceptual shifts characteristic of classical psychedelics.[1]

Subjective effects include enhanced self-awareness, emotional depth, altered associative thinking, and closed-eye visuals.[2] The experience is defined by cognitive and emotional richness — warm and introspective — with notably subdued open-eye visual activity and preserved intellectual clarity even at higher doses.

DOET produces no physical dependence; rapid tolerance through serotonin downregulation makes compulsive redosing self-limiting.[3] The primary danger is duration-related — sustained cardiovascular stimulation across the extended experience, compounded by a slow onset that invites premature redosing and potentially overwhelming effects.[4]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 1 mgLight1 – 2 mgCommon2 – 4 mgStrong4 – 6 mgHeavy7+ mg

Starts in 1 – 3 hoursLasts 14 – 20 hoursAfter-effects 6 – 24 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
LSD; mescaline; DOM; DOB; DOI; psilocybin

Effectslikely at a common dose

Perception
Geometry; Visual drifting; Visual morphing; Color enhancement; Color alteration; Visual breathing; +30 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
Body
Stimulation; Wakefulness; Insomnia; Pupil dilation; Appetite suppression; Vasoconstriction; Dry mouth; +25 possible, including Muscle tension, Excessive sweating, Headache
Thinking
Aesthetic enhancement; Novelty enhancement; +32 possible, including Thought loops, Suggestibility enhancement, Information processing suppression
Feeling
Emotional enhancement; +9 possible, including Emotional lability, Anxiety, Paranoia
Self
none likely · 12 possible, including Derealization, Depersonalization, Ego inflation
Time
Time alteration; +3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 4 possible

Who shouldn't take it

Absolute
Pre-existing cardiovascular conditions; Psychotic disorders, bipolar disorder, severe anxiety disorders; Pregnancy and lactation
Relative
Seizure disorders; Significant liver disease; Concurrent MAOI use

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (18)
MDMA, MDA; NRIs; Buspirone; Dopamine agonists; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/doet
Not graded (5)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Nelson DL, Lucaites VL, Wainscott DB, Glennon RA (1999) Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors. — Naunyn-Schmiedeberg's Archives of Pharmacology PMID:9933142
  2. [2]
    ^Shulgin AT, Shulgin A (1991) PiHKAL #66: DOET Link
  3. [3]
    ^de la Fuente Revenga M, Jaster AM, McGinn J, Silva G, Saha S, Gonzalez-Maeso J (2022) Tolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HT2A Receptor Agonists in Mice — ACS Chemical Neuroscience doi:10.1021/acschemneuro.2c00170
  4. [4]
    ^Huang J, Ho BT (1975) Some pharmacological actions of 2,5-dimethoxy-4-ethylamphetamine (DOET) in rats and mice. — The Journal of Pharmacy and Pharmacology PMID:235610
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