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Psychedex
Facts label

DOC Facts

Psychedelic; Substituted amphetamine; Serotonin 2A receptor agonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 0.5 mgLight1 – 1.5 mgCommon1.5 – 2.5 mgStrong2.5 – 3.5 mgHeavy3.5+ mg

Starts in 1 – 3 hoursLasts 12 – 24 hoursAfter-effects 6 – 24 hours

Also recorded: Insufflated. See full page: psychedex.org/substances/doc

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
LSD; psilocybin; mescaline; DOM; DOI; DOB

Effectslikely at a common dose

Perception
Color enhancement; Visual drifting; Color alteration; Depth perception distortion; Perspective distortion; Tracers; After-images; Visual diffraction; Music enhancement; Auditory enhancement; Brightness alteration; Symmetrical texture repetition; Dreaming suppression; Environmental patterning; Geometry; Holotropic state; Light sensitivity; Peripheral vision distortion; Sound sensitivity; Visual breathing; Visual morphing; +16 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
Body
Stimulation; Spontaneous body sensations; Appetite suppression; Excessive sweating; Muscle tension; Dehydration sensation; Dry mouth; Restlessness; Pupil dilation; Wakefulness; Vasoconstriction; Body high; Body scan awareness; Heart rate perception changes; Insomnia; Physical fatigue; +26 possible, including Temperature dysregulation, Nausea, Motor control impairment
Thinking
Pattern recognition enhancement; Conceptual thinking; Thought acceleration; Cognitive euphoria; Novelty enhancement; Immersion enhancement; Thought connectivity; Aesthetic enhancement; Cognitive fatigue; Cognitive flexibility; Creativity enhancement; Increased nature relatedness; Introspection enhancement; Multiple thought streams; Openness enhancement; +18 possible, including Cognitive impairment, Confusion, Decision impairment
Feeling
Emotional enhancement; Emotional lability; Euphoria; Simultaneous emotions; +8 possible, including Anxiety, Paranoia, Depression
Self
Derealization; Emotional susceptibility; +9 possible, including Depersonalization, Ego inflation, Compulsive repetitive behavior
Time
Time alteration; Present-moment absorption; Temporal disorientation; +2 possible
Transpersonal
none likely · 1 possible
Awareness
Personal insight; +3 possible

Who shouldn't take it

Absolute
Psychotic disorders; Bipolar disorder; Pregnancy; Lithium co-administration; MAOI co-administration
Relative
Cardiovascular disease; Epilepsy

Combinations60 recorded

Lethal (1)
MAOIs
Dangerous (26)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Ephedrine, Pseudoephedrine; GHB, GBL; Local anesthetics; MDMA, MDA; NRIs; Opioids; SSRIs; Stimulants; 5-HTP, Tryptophan; Antipsychotics; Buspirone; Caffeine; Dopamine agonists; DXM; GHB, Baclofen; Ibogaine; Ketamine, DXM, PCP; Lithium; NDRIs (Wellbutrin); NSAIDs; Psychedelics; Salvia, Ibogaine; and 2 more, see full page
Caution (29)
See full page: psychedex.org/substances/doc
Not graded (4)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/doc · Version r1 · Not medical adviceValues as of
On the printout