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Psychedex
Facts label

Deschloroketamine Facts

Dissociative; Arylcyclohexylamine; NMDA receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight10 – 20 mgCommon15 – 30 mgStrong25 – 50 mgHeavy50+ mg

Starts in 15 – 30 minLasts 4 – 6 hoursAfter-effects 2 – 12 hours

Also recorded: Smoked · Insufflated. See full page: psychedex.org/substances/deschloroketamine

Body and dependence

Acute toxicity
Low
Chronic toxicity
Moderate
Physical dependence
Low
Psychological dependence
Moderate
Withdrawal
Mild
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
10 days
Carries over to
ketamine; phencyclidine; methoxetamine; 2-fluorodeschloroketamine; 3-MeO-PCP; dextromethorphan

Effectslikely at a common dose

Perception
Spatial disorientation; Sensory deprivation; +32 possible, including Visual acuity suppression, Vestibular distortion, Double vision
Body
Pain suppression; Motor control impairment; Sedation; Nystagmus (eye wobbles); +25 possible, including Dizziness, Nausea, Headache
Thinking
Decision impairment; Cognitive impairment; +31 possible, including Confusion, Information processing suppression, Thought disorganization
Feeling
Euphoria; +7 possible, including Anxiety, Dysphoria, Emotional lability
Self
Communication suppression; Depersonalization; Derealization; +7 possible, including Social disconnection, Craving
Time
Temporal disorientation; Time alteration; +2 possible
Transpersonal
none likely · 1 possible
Awareness
none likely · 3 possible

Who shouldn't take it

Absolute
Psychotic disorders; Pregnancy
Relative
Uncontrolled hypertension; Epilepsy; Bipolar disorder; Hepatic impairment; Urological conditions

Combinations61 recorded

Lethal (1)
GHB, GBL
Dangerous (30)
Antihistamines; Benzodiazepines; Benzodiazepines, Barbiturates; Buprenorphine, Kratom; Naltrexone; NSAIDs; Opioids; THC; Anticholinergics; Antipsychotics; Buspirone; Clonidine, Guanfacine; Dopamine agonists; Gabapentin, Pregabalin; GHB, Baclofen; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; and 6 more, see full page
Caution (24)
See full page: psychedex.org/substances/deschloroketamine
Not graded (6)
Not listed never means safe.

Seek help immediately if

  • Severe disorientation; unable to move or speak (deep dissociation / "k-hole")
  • Complete loss of coordination — cannot stand or walk safely
  • Vomiting while incapacitated (choking / aspiration risk)
  • Very high blood pressure; fast heart rate
  • Slow or shallow breathing at high doses (especially mixed with depressants)
  • Unconsciousness; rarely, seizures

What to do

  1. Move them somewhere safe, away from stairs, water, roads, and sharp edges — they cannot protect themselves
  2. Place in the recovery position if vomiting or unconscious (aspiration is a key risk)
  3. Stay with them and reassure calmly; keep the environment quiet
  4. If breathing is slow/shallow or they are unresponsive, call emergency services
  5. Do not let them wander; do not leave them alone
  6. Be ready to give rescue breaths / CPR

Effects wear off with time in a safe, monitored setting. The main dangers are physical injury and aspiration while incapacitated, and respiratory depression when combined with other depressants — not the dissociation itself.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/deschloroketamine · Version r1 · Not medical adviceValues as of
On the printout