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Psychedex
Facts label

Δ-8-Tetrahydrocannabinol Facts

Cannabinoid; Cannabinoid; Cannabinoid CB1 receptor partial agonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight5 – 15 mgCommon15 – 40 mgStrong40 – 80 mgHeavy80+ mg

Starts in 30 – 120 minLasts 4 – 8 hoursAfter-effects 2 – 12 hours

Also recorded: Vaporized. See full page: psychedex.org/substances/delta-8-thc

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
Low
Psychological dependence
Moderate
Withdrawal
Mild
Compulsive redosing
Low

Tolerance

Builds
Moderate
Fully resets after
21 days
Carries over to
Δ9-THC; WIN 55,212-2; Synthetic cannabinoids (CB1 agonists)

Effectslikely at a common dose

Perception
none likely · 15 possible, including Spatial disorientation, Vestibular distortion
Body
Body high; Dry mouth; +16 possible, including Heart rate perception changes, Motor control impairment, Abnormal heartbeat
Thinking
none likely · 31 possible, including Cognitive impairment, Memory suppression, Decision impairment
Feeling
Euphoria; +5 possible, including Anxiety, Emotional lability, Paranoia
Self
none likely · 10 possible, including Craving, Depersonalization, Derealization
Time
Time alteration; +1 possible
Awareness
none likely · 2 possible

Who shouldn't take it

Absolute
History of psychotic disorders; Pregnancy and lactation; Pediatric populations
Relative
Cardiovascular disease; Hepatic impairment; Anticoagulant therapy (warfarin)

Combinations60 recorded

Dangerous (11)
Ketamine, DXM, PCP; Opioids; GHB, Baclofen; GHB, GBL; Ibogaine; Local anesthetics; MAOIs; NDRIs (Wellbutrin); Salvia, Ibogaine; SNRIs; Synthetic cannabinoids
Caution (34)
See full page: psychedex.org/substances/delta-8-thc
Not graded (15)
Not listed never means safe.

Seek help immediately if

Natural cannabis rarely causes a medical emergency — "greening out" is: pale/sweaty skin, dizziness, nausea or vomiting, anxiety or panic, rapid heartbeat, feeling faint — and usually passes with rest.

Seek emergency help for these — far more likely with synthetic cannabinoids ("spice" / K2):

  • Seizures
  • Severe chest pain; very fast or irregular heartbeat
  • Unresponsiveness or extreme drowsiness
  • Severe agitation, aggression, or psychosis
  • Repeated vomiting; difficulty breathing

What to do

  1. Sit or lie them down somewhere calm, cool, and quiet
  2. Reassure them — cannabis panic and "greening out" pass with time
  3. Offer sips of water; a little sugar can help if they feel faint
  4. Recovery position if nauseated, drowsy, or vomiting
  5. Stay with them and monitor
  6. For seizures, chest pain, unresponsiveness, or severe agitation, call emergency services

Natural cannabis "greening out" resolves with rest, calm, and time, with no lasting harm. Synthetic cannabinoids are unpredictable and can cause seizures, cardiac events, kidney injury, and severe agitation that needs emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/delta-8-thc · Version r1.a1 · Not medical adviceValues as of
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