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Δ-11-Tetrahydrocannabinol Facts

Cannabinoid; Cannabinoid; Cannabinoid CB1 receptor partial agonist

Dose and duration

No dose or duration recorded for any route.

Body and dependence

Acute toxicity
Low
Chronic toxicity
Not assessed
Physical dependence
Negligible
Psychological dependence
Low
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Slow
Fully resets after
3 weeks
Carries over to
Δ9-THC; Δ8-THC; other CB1 agonists

Effectslikely at a common dose

Perception
none likely · 20 possible, including Spatial disorientation, Vestibular distortion, Visual acuity suppression
Body
Body high; Body scan awareness; Dry mouth; +22 possible, including Heart rate perception changes, Motor control impairment, Dizziness
Thinking
none likely · 35 possible, including Cognitive impairment, Memory suppression, Decision impairment
Feeling
Euphoria; +8 possible, including Anxiety, Paranoia, Emotional lability
Self
none likely · 10 possible, including Derealization, Communication suppression, Craving
Time
Time alteration; +3 possible, including Temporal disorientation

Who shouldn't take it

Absolute
Pregnancy and lactation
Relative
Cardiovascular disease; Psychotic disorders; Concurrent sympathomimetic or epinephrine use

Combinations60 recorded

Dangerous (11)
Ketamine, DXM, PCP; Opioids; GHB, Baclofen; GHB, GBL; Ibogaine; Local anesthetics; MAOIs; NDRIs (Wellbutrin); Salvia, Ibogaine; SNRIs; Synthetic cannabinoids
Caution (34)
See full page: psychedex.org/substances/delta-11-thc
Not graded (15)
Not listed never means safe.

Seek help immediately if

Natural cannabis rarely causes a medical emergency — "greening out" is: pale/sweaty skin, dizziness, nausea or vomiting, anxiety or panic, rapid heartbeat, feeling faint — and usually passes with rest.

Seek emergency help for these — far more likely with synthetic cannabinoids ("spice" / K2):

  • Seizures
  • Severe chest pain; very fast or irregular heartbeat
  • Unresponsiveness or extreme drowsiness
  • Severe agitation, aggression, or psychosis
  • Repeated vomiting; difficulty breathing

What to do

  1. Sit or lie them down somewhere calm, cool, and quiet
  2. Reassure them — cannabis panic and "greening out" pass with time
  3. Offer sips of water; a little sugar can help if they feel faint
  4. Recovery position if nauseated, drowsy, or vomiting
  5. Stay with them and monitor
  6. For seizures, chest pain, unresponsiveness, or severe agitation, call emergency services

Natural cannabis "greening out" resolves with rest, calm, and time, with no lasting harm. Synthetic cannabinoids are unpredictable and can cause seizures, cardiac events, kidney injury, and severe agitation that needs emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/delta-11-thc · Version r1 · Not medical adviceValues as of
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