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Δ-10-Tetrahydrocannabinol Facts

Cannabinoid; Cannabinoid; Cannabinoid CB1 receptor partial agonist

Description

Δ10-THC (delta-10-tetrahydrocannabinol) is a semi-synthetic cannabinoid of the terpenophenolic class. Unusually, it blocks rather than activates the brain's primary cannabinoid receptor.[1]

Subjective effects include mild euphoria, mental stimulation, relaxation, and less anxiety than Δ9-THC. The experience is clear-headed and energizing — closer to a sativa-type cannabis feel than the heavier sedation typical of other THC isomers.

No dependence data exist and no lethal dose has been established. The chief danger is product quality: the chemical conversion process used to make it can leave unknown byproducts and contaminants.[2]

Dose and durationby route · individual sensitivity varies

Oral

No dose recorded for this route. The timings are not a dose guide.

Starts in 30 – 90 minLasts 4 – 8 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Not assessed
Physical dependence
Low
Psychological dependence
Low
Withdrawal
Mild
Compulsive redosing
Low

Tolerance

Builds
Moderate
Fully resets after
21 days
Carries over to
Δ9-THC; Δ8-THC; other CB1 receptor agonists

Who shouldn't take it

Absolute
Pregnancy and breastfeeding; Pediatric exposure risk
Relative
Pre-existing cardiovascular disease; Depression, anxiety disorders, or suicidal ideation history; Concurrent warfarin or anticoagulant therapy; Operating vehicles or machinery

Combinations60 recorded

Dangerous (11)
Ketamine, DXM, PCP; Opioids; GHB, Baclofen; GHB, GBL; Ibogaine; Local anesthetics; MAOIs; NDRIs (Wellbutrin); Salvia, Ibogaine; SNRIs; Synthetic cannabinoids
Caution (34)
See full page: psychedex.org/substances/delta-10-thc
Not graded (15)
Not listed never means safe.

Seek help immediately if

Natural cannabis rarely causes a medical emergency — "greening out" is: pale/sweaty skin, dizziness, nausea or vomiting, anxiety or panic, rapid heartbeat, feeling faint — and usually passes with rest.

Seek emergency help for these — far more likely with synthetic cannabinoids ("spice" / K2):

  • Seizures
  • Severe chest pain; very fast or irregular heartbeat
  • Unresponsiveness or extreme drowsiness
  • Severe agitation, aggression, or psychosis
  • Repeated vomiting; difficulty breathing

What to do

  1. Sit or lie them down somewhere calm, cool, and quiet
  2. Reassure them — cannabis panic and "greening out" pass with time
  3. Offer sips of water; a little sugar can help if they feel faint
  4. Recovery position if nauseated, drowsy, or vomiting
  5. Stay with them and monitor
  6. For seizures, chest pain, unresponsiveness, or severe agitation, call emergency services

Natural cannabis "greening out" resolves with rest, calm, and time, with no lasting harm. Synthetic cannabinoids are unpredictable and can cause seizures, cardiac events, kidney injury, and severe agitation that needs emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1.a1 · Not medical advice

References

  1. [1]
    ^Haghdoost M, Brumar D, Geiling B, Brunstetter M, Bonn-Miller MO (2023) Chemistry, Crystal Structure, and In Vitro Receptor Binding of Δ10-THC Isomers — Cannabis and Cannabinoid Research doi:10.1089/can.2023.0045
  2. [2]
    ^Ray CL, Bylo MP, Pescaglia J, Gawenis JA, Greenlief CM (2022) Delta-8 Tetrahydrocannabinol Product Impurities — Molecules doi:10.3390/molecules27206924
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