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Cyclazodone Facts

Stimulant; Nootropic; Aminorex; Norepinephrine-dopamine reuptake inhibitor

Description

Cyclazodone is a synthetic stimulant of the oxazolidinone class. It raises dopamine and norepinephrine levels in the brain, producing the focused, wakeful drive characteristic of stimulants.[1][2]

Subjective effects include focus enhancement, motivation, improved cognitive performance, and mild mood elevation. The experience is task-oriented and context-dependent — structured work feels more absorbing, but the same dose without purposeful activity produces directionless restlessness.[3]

Dependence liability is presumed moderate; the primary toxicity concern is liver damage inherited from the pemoline class. Pemoline caused fatal liver failure in at least 21 patients,[4] and structural similarity to cyclazodone gives no reason to assume that risk is gone.[5]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight5 – 15 mgCommon15 – 25 mgStrong25 – 60 mgHeavy60+ mg

Starts in 20 – 45 minLasts 5 – 7 hoursAfter-effects 2 – 6 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
High
Physical dependence
Low
Psychological dependence
Moderate
Withdrawal
Mild
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
10.5 days
Carries over to
amphetamine; methylphenidate; cocaine; other dopaminergic stimulants

Effectslikely at a common dose

Perception
none likely · 4 possible
Body
Stimulation; Appetite suppression; Pupil dilation; Wakefulness; +20 possible, including Vasoconstriction, Insomnia, Muscle tension
Thinking
none likely · 20 possible, including Cognitive dysphoria, Compulsive redosing urge
Feeling
none likely · 7 possible, including Anxiety, Anhedonia, Depression
Self
none likely · 8 possible, including Ego inflation, Craving
Time
none likely · 2 possible

Who shouldn't take it

Absolute
Baseline QTc prolongation or cardiac arrhythmia; Hepatic impairment or liver disease; Pregnancy; Concurrent MAO inhibitor use; Concurrent tramadol use
Relative
Cardiovascular disease; Seizure disorders; History of stimulant psychosis; Concurrent SSRI use

Combinations61 recorded

Lethal (1)
Tramadol
Dangerous (29)
Amphetamines; Ephedrine, Pseudoephedrine; Local anesthetics; MAOIs; MDMA, Amphetamines; NRIs; Stimulants; Alpha-2 adrenergic receptor antagonist; Anticholinergics; Antipsychotics; Caffeine; Clonidine, Guanfacine; Dopamine agonists; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; MDMA, MDA; NSAIDs; Opioids; Poppers (Alkyl nitrites); Poppers, Nitrates; Psychedelics; and 5 more, see full page
Caution (27)
See full page: psychedex.org/substances/cyclazodone
Not graded (4)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Docherty JR (2008) Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA). — British Journal of Pharmacology doi:10.1038/bjp.2008.124
  2. [2]
    ^Luethi D, Liechti ME (2020) Designer drugs: mechanism of action and adverse effects — Archives of Toxicology doi:10.1007/s00204-020-02693-7
  3. [3]
    ^Bluelight.org community (2022) Cyclazodone Megathread - Bluelight.org Link
  4. [4]
    ^Marotta PJ, Roberts EA (1998) Pemoline hepatotoxicity in children — The Journal of Pediatrics PMID:9602211
  5. [5]
    ^CFSRE (2022) Toxicity from the NPS N-Methyl-Cyclazodone with Laboratory Confirmation - A Dance Befitting St. Vitus Link
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