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Psychedex
Facts label

Cannabidiol Facts

Cannabinoid; Cannabinoid; Cannabinoid CB1 negative allosteric modulator

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 2 mgLight5 – 15 mgCommon15 – 30 mgStrong30 – 60 mgHeavy60+ mg

Starts in 15 – 45 minLasts 1.5 – 4 hoursAfter-effects 2 – 6 hours

Body and dependence

Acute toxicity
Negligible
Chronic toxicity
Moderate
Physical dependence
None
Psychological dependence
None
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
None
Fully resets after
Not recorded

Effectslikely at a common dose

Body
none likely · 5 possible, including Diarrhea
Feeling
none likely · 1 possible

Who shouldn't take it

Absolute
Severe hepatic impairment; Pregnancy and lactation
Relative
Concurrent valproate without liver function monitoring; Concurrent CYP2C19 substrate medications without dose adjustment; Concurrent strong CYP3A4 inducers; Age under 25 for non-medical use

Combinations60 recorded

Dangerous (19)
MAOIs; MDMA, MDA; Alpha-2 adrenergic receptor antagonist; Caffeine; Dopamine agonists; DXM; GHB, Baclofen; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NRIs; Opioids; Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Ibogaine; Synthetic cannabinoids
Caution (35)
See full page: psychedex.org/substances/cbd
Not graded (6)
Not listed never means safe.

Seek help immediately if

Natural cannabis rarely causes a medical emergency — "greening out" is: pale/sweaty skin, dizziness, nausea or vomiting, anxiety or panic, rapid heartbeat, feeling faint — and usually passes with rest.

Seek emergency help for these — far more likely with synthetic cannabinoids ("spice" / K2):

  • Seizures
  • Severe chest pain; very fast or irregular heartbeat
  • Unresponsiveness or extreme drowsiness
  • Severe agitation, aggression, or psychosis
  • Repeated vomiting; difficulty breathing

What to do

  1. Sit or lie them down somewhere calm, cool, and quiet
  2. Reassure them — cannabis panic and "greening out" pass with time
  3. Offer sips of water; a little sugar can help if they feel faint
  4. Recovery position if nauseated, drowsy, or vomiting
  5. Stay with them and monitor
  6. For seizures, chest pain, unresponsiveness, or severe agitation, call emergency services

Natural cannabis "greening out" resolves with rest, calm, and time, with no lasting harm. Synthetic cannabinoids are unpredictable and can cause seizures, cardiac events, kidney injury, and severe agitation that needs emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/cbd · Version r1 · Not medical adviceValues as of
On the printout