Skip to main content
Psychedex
Facts label

Cannabis Facts

Cannabinoid; Cannabinoid; Cannabinoid CB1 receptor partial agonist

Dose and durationby route · individual sensitivity varies

Oral(mg THC)
Threshold< 2.5 mg THCLight2.5 – 5 mg THCCommon5 – 15 mg THCStrong15 – 30 mg THCHeavy50+ mg THC

Starts in 30 – 120 minLasts 4 – 8 hoursAfter-effects 2 – 6 hours

Also recorded: Sublingual · Smoked · Vaporized. See full page: psychedex.org/substances/cannabis

Body and dependence

Acute toxicity
Low
Chronic toxicity
Moderate
Physical dependence
Moderate
Psychological dependence
Moderate
Withdrawal
Moderate
Compulsive redosing
Low

Tolerance

Builds
Moderate
Fully resets after
17.5 days
Carries over to
Synthetic cannabinoids; Other plant-derived CB1 agonists

Effectslikely at a common dose

Perception
Music enhancement; +18 possible, including Vestibular distortion, Visual acuity suppression, Spatial disorientation
Body
Dry mouth; Body high; Heart rate perception changes; +20 possible, including Motor control impairment, Abnormal heartbeat, Dizziness
Thinking
Cognitive euphoria; Memory suppression; +29 possible, including Cognitive impairment, Decision impairment, Analysis suppression
Feeling
Euphoria; +7 possible, including Anxiety, Paranoia, Emotional lability
Self
none likely · 8 possible, including Craving
Time
Time alteration; +2 possible, including Temporal disorientation
Awareness
none likely · 2 possible

Who shouldn't take it

Absolute
Pregnancy
Relative
Significant cardiovascular disease; Respiratory disease (smoked preparations); Personal or family history of psychotic disorders; Hepatic impairment; Adolescence (under 25); Concurrent CYP2C9 substrates (e.g., warfarin); Concurrent CYP3A4 substrates (e.g., midazolam); Concurrent CNS depressants (opioids, benzodiazepines, alcohol)

Combinations60 recorded

Dangerous (11)
Ketamine, DXM, PCP; Opioids; GHB, Baclofen; GHB, GBL; Ibogaine; Local anesthetics; MAOIs; NDRIs (Wellbutrin); Salvia, Ibogaine; SNRIs; Synthetic cannabinoids
Caution (33)
See full page: psychedex.org/substances/cannabis
Not graded (16)
Not listed never means safe.

Seek help immediately if

Natural cannabis rarely causes a medical emergency — "greening out" is: pale/sweaty skin, dizziness, nausea or vomiting, anxiety or panic, rapid heartbeat, feeling faint — and usually passes with rest.

Seek emergency help for these — far more likely with synthetic cannabinoids ("spice" / K2):

  • Seizures
  • Severe chest pain; very fast or irregular heartbeat
  • Unresponsiveness or extreme drowsiness
  • Severe agitation, aggression, or psychosis
  • Repeated vomiting; difficulty breathing

What to do

  1. Sit or lie them down somewhere calm, cool, and quiet
  2. Reassure them — cannabis panic and "greening out" pass with time
  3. Offer sips of water; a little sugar can help if they feel faint
  4. Recovery position if nauseated, drowsy, or vomiting
  5. Stay with them and monitor
  6. For seizures, chest pain, unresponsiveness, or severe agitation, call emergency services

Natural cannabis "greening out" resolves with rest, calm, and time, with no lasting harm. Synthetic cannabinoids are unpredictable and can cause seizures, cardiac events, kidney injury, and severe agitation that needs emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/cannabis · Version r2 · Not medical adviceValues as of
On the printout