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Caffeine Facts

Stimulant; Purine alkaloid; Adenosine A1/A2A receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 10 mgLight20 – 100 mgCommon100 – 300 mgStrong300 – 500 mgHeavy500+ mg

Starts in 10 – 30 minLasts 3 – 6 hoursAfter-effects 2 – 6 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
Low
Psychological dependence
Low
Withdrawal
Mild
Compulsive redosing
Low

Tolerance

Builds
Moderate
Fully resets after
10 days
Carries over to
theophylline; theobromine; paraxanthine

Effectslikely at a common dose

Body
Wakefulness; Stimulation; +16 possible, including Insomnia, Vasoconstriction, Headache
Thinking
none likely · 14 possible, including Compulsive redosing urge
Feeling
none likely · 4 possible, including Anxiety, Depression
Self
none likely · 5 possible, including Craving
Awareness
Sustained attention (vicara); +1 possible

Who shouldn't take it

Absolute
Panic disorder; Neonates and infants
Relative
Uncontrolled hypertension; Cardiac arrhythmias; Generalized anxiety disorder; CYP1A2 inhibitor co-administration; Pregnancy

Combinations61 recorded

Dangerous (18)
Amphetamines; Ephedrine, Pseudoephedrine; CBD; GHB, Baclofen; GHB, GBL; Ibogaine; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids; Salvia, Ibogaine
Caution (30)
See full page: psychedex.org/substances/caffeine
Not graded (13)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/caffeine · Version r1 · Not medical adviceValues as of
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