Caffeine Facts
Stimulant;
Dose and durationby route · individual sensitivity varies
Oral(mg)
Threshold< 10 mgLight20 – 100 mgCommon100 – 300 mgStrong300 – 500 mgHeavy500+ mg
Starts in 10 – 30 minLasts 3 – 6 hoursAfter-effects 2 – 6 hours
Body and dependence
- Acute toxicity
- Low
- Chronic toxicity
- Low
- Physical dependence
- Low
- Psychological dependence
- Low
- Withdrawal
- Mild
- Compulsive redosing
- Low
Tolerance
- Builds
- Moderate
- Fully resets after
- 10 days
- Carries over to
- theophylline;
theobromine; paraxanthine
Effectslikely at a common dose
- Perception
- none likely · 3 possible
- Body
- Wakefulness;
Stimulation; +16 possible, including Insomnia, Vasoconstriction, Headache - Thinking
- none likely · 14 possible, including Compulsive redosing urge
- Feeling
- none likely · 4 possible, including Anxiety, Depression
- Self
- none likely · 5 possible, including Craving
- Awareness
- Sustained attention (vicara);
+1 possible
Who shouldn't take it
Absolute
Panic disorder; Neonates and infants
Relative
Uncontrolled hypertension; Cardiac arrhythmias; Generalized anxiety disorder; CYP1A2 inhibitor co-administration; Pregnancy
Combinations61 recorded
Dangerous (18)
Amphetamines; Ephedrine, Pseudoephedrine; CBD; GHB, Baclofen; GHB, GBL; Ibogaine; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids; Salvia, Ibogaine
Caution (30)
See full page: psychedex.org/substances/caffeine
Not graded (13)
Not listed never means safe.
Seek help immediately if
No emergency profile is recorded for this substance. Not recorded never means no risk.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
psychedex.org/substances/caffeine · Version r1 · Not medical adviceValues as of