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Psychedex
Facts label

Amphetamine Facts

Stimulant; Substituted amphetamine; Dopamine releasing agent

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight5 – 15 mgCommon15 – 30 mgStrong30 – 50 mgHeavy50+ mg

Starts in 15 – 30 minLasts 4 – 8 hoursAfter-effects 6 – 24 hours

Also recorded: Insufflated · Intravenous. See full page: psychedex.org/substances/amphetamine

Body and dependence

Acute toxicity
Low
Chronic toxicity
Moderate
Physical dependence
Low
Psychological dependence
High
Withdrawal
Moderate
Compulsive redosing
High

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
methamphetamine; cocaine; methylphenidate; other dopaminergic stimulants

Effectslikely at a common dose

Perception
Dreaming suppression; +6 possible
Body
Physical fatigue; Wakefulness; Insomnia; Stimulation; Appetite suppression; Pupil dilation; +22 possible, including Dehydration sensation, Vasoconstriction, Abnormal heartbeat
Thinking
Cognitive euphoria; Focus enhancement; Thought acceleration; +19 possible, including Compulsive redosing urge, Cognitive dysphoria
Feeling
Euphoria; +8 possible, including Depression, Dysphoria, Anxiety
Self
none likely · 8 possible, including Craving, Ego inflation
Time
none likely · 2 possible
Awareness
Sustained attention (vicara); +1 possible

Who shouldn't take it

Absolute
Structural heart disease; Psychotic disorders; Pregnancy; MAOI co-administration
Relative
Hypertension; Seizure disorders; Bipolar disorder; Hyperthyroidism; Glaucoma

Combinations61 recorded

Lethal (3)
Ibogaine; MAOIs; Tramadol
Dangerous (33)
Anticholinergics; Atypical antipsychotics; Benzodiazepines, Barbiturates; Caffeine; Dopamine agonists; Ephedrine, Pseudoephedrine; Local anesthetics; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; Psychedelics; SNRIs; SSRIs; Stimulants; 5-HTP, Tryptophan; Alpha-2 adrenergic receptor antagonist; Antihistamines; Antipsychotics; Buspirone; Clonidine, Guanfacine; DXM; GHB, Baclofen; and 9 more, see full page
Caution (22)
See full page: psychedex.org/substances/amphetamine
Not graded (3)
Not listed never means safe.

Seek help immediately if

  • Chest pain; racing, pounding, or irregular heartbeat
  • Very high body temperature; heavy sweating; hot, flushed skin
  • Severe agitation, paranoia, panic, or confusion
  • Severe headache; muscle rigidity or twitching
  • Seizures
  • Signs of stroke — face drooping, one-sided weakness, slurred speech
  • Difficulty breathing; collapse or unconsciousness

What to do

  1. Call emergency services for chest pain, overheating, seizure, or unresponsiveness
  2. Move them to a cool, quiet place and reduce stimulation
  3. Cool the body — remove excess clothing, apply cool damp cloths, fan them
  4. Keep them calm; reassure — panic worsens the cardiovascular strain
  5. If seizing, protect from injury (don't restrain); recovery position afterward
  6. Monitor breathing and be ready to give rescue breaths / CPR

Most stimulant overdoses settle with cooling, a calm environment, and time. The medical danger is hyperthermia, cardiac events (arrhythmia, heart attack, stroke), and seizures — get help immediately if any appear.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/amphetamine · Version r1 · Not medical adviceValues as of
On the printout