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Psychedex
Facts label

Alprazolam Facts

Depressant; Anxiolytic; Benzodiazepine; GABA-A receptor positive allosteric modulator

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 0.125 mgLight0.25 – 0.5 mgCommon0.5 – 1.5 mgStrong1.5 – 3 mgHeavy4+ mg

Starts in 15 – 30 minLasts 4 – 8 hoursAfter-effects 6 – 24 hours

Also recorded: Sublingual. See full page: psychedex.org/substances/alprazolam

Body and dependence

Acute toxicity
Low
Chronic toxicity
Moderate
Physical dependence
High
Psychological dependence
High
Withdrawal
Severe · fatal · medical supervision
Compulsive redosing
Moderate

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
diazepam; clonazepam; lorazepam; triazolam; zolpidem; zopiclone; alcohol; barbiturates

Effectslikely at a common dose

Perception
none likely · 3 possible, including Visual acuity suppression, Spatial disorientation
Body
Sedation; Muscle relaxation; Motor control impairment; +9 possible, including Dizziness, Headache, Nausea
Thinking
Analysis suppression; Memory suppression; Thought deceleration; +12 possible, including Delusions of sobriety, Cognitive impairment, Decision impairment
Feeling
Anxiety suppression; +3 possible
Self
none likely · 4 possible, including Communication suppression, Craving
Time
none likely · 2 possible, including Temporal disorientation

Who shouldn't take it

Absolute
Severe respiratory insufficiency; Sleep apnea syndrome; Known hypersensitivity to benzodiazepines; Acute narrow-angle glaucoma; Concurrent opioid use
Relative
Post-traumatic stress disorder; Borderline personality disorder; Bipolar disorder; Severe hepatic impairment; Pregnancy; Elderly

Combinations60 recorded

Lethal (1)
Opioids
Dangerous (21)
Alpha-2 adrenergic receptor antagonist; Antipsychotics; Atypical antipsychotics; Benzodiazepines; Buprenorphine, Kratom; Cannabis, THC; Clonidine, Guanfacine; Gabapentin, Pregabalin; GHB, Baclofen; GHB, GBL; Local anesthetics; Naltrexone; SNRIs; Stimulants; Synthetic cannabinoids; Ibogaine; Ketamine, DXM, PCP; MAOIs; NSAIDs; Poppers (Alkyl nitrites); Poppers, Nitrates
Caution (26)
See full page: psychedex.org/substances/alprazolam
Not graded (12)
Not listed never means safe.

Seek help immediately if

  • Extreme drowsiness — can't stay awake or be roused
  • Confusion, slurred speech, severe loss of coordination
  • Slow, shallow, or irregular breathing
  • Unconsciousness / unresponsive; limp, floppy body
  • Blue lips or fingertips
  • Vomiting while sedated (choking / aspiration risk)
  • Cold, clammy skin; weak pulse

What to do

  1. Try to wake them — shout, firm sternal rub
  2. If unresponsive or breathing is impaired, call emergency services
  3. Place them in the recovery position — critical, they can choke on vomit
  4. Monitor breathing continuously; be ready to give rescue breaths / CPR
  5. Never leave them alone to "sleep it off"
  6. Do not give other drugs, stimulants, or more depressants

Most depressant overdoses resolve with airway protection, breathing support, and monitoring. The danger is respiratory depression and choking on vomit — sharply worse when combined with opioids or alcohol. GHB/GBL overdoses often involve sudden deep unconsciousness and may self-resolve, but airway protection is essential.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/alprazolam · Version r1 · Not medical adviceValues as of
On the printout