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Psychedex
Facts label

α-PHP Facts

Stimulant; Substituted cathinone; Dopamine reuptake inhibitor

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 3 mgLight5 – 15 mgCommon10 – 25 mgStrong25 – 40 mgHeavy40+ mg

Starts in 15 – 45 minLasts 8 – 16 hoursAfter-effects 4 – 10 hours

Also recorded: Sublingual · Rectal · Smoked · Insufflated · Intravenous. See full page: psychedex.org/substances/alpha-php

Body and dependence

Acute toxicity
High
Chronic toxicity
Moderate
Physical dependence
Low
Psychological dependence
High
Withdrawal
Moderate
Compulsive redosing
High

Tolerance

Builds
Moderate
Fully resets after
14 days
Carries over to
cocaine; methylphenidate; α-PVP; pyrovalerone; MDPV; other pyrovalerone cathinones

Effectslikely at a common dose

Perception
Dreaming suppression; +1 possible
Body
Appetite suppression; Body high; Dry mouth; Heart rate perception changes; Insomnia; Pupil dilation; Restlessness; Stimulation; Vasoconstriction; Wakefulness; +16 possible, including Dehydration sensation, Excessive sweating, Muscle tension
Thinking
Cognitive euphoria; Compulsive redosing urge; Thought acceleration; +9 possible, including Thought loops, Cognitive dysphoria, Cognitive impairment
Feeling
Euphoria; +4 possible, including Anxiety, Dysphoria, Paranoia
Self
none likely · 8 possible, including Craving, Compulsive repetitive behavior, Ego inflation
Time
none likely · 1 possible

Who shouldn't take it

Absolute
Severe cardiovascular disease; Pregnancy; Breastfeeding; Concurrent MAOI use
Relative
Seizure disorders; Psychotic disorders; Bipolar disorder; Hepatic impairment; Renal impairment

Combinations61 recorded

Lethal (1)
Ibogaine
Dangerous (29)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Benzodiazepines, Barbiturates; Ephedrine, Pseudoephedrine; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; SSRIs; Stimulants; Anticholinergics; Antipsychotics; Buspirone; Caffeine; Dopamine agonists; DXM; GHB, Baclofen; GHB, GBL; Ketamine, DXM, PCP; Lithium; NSAIDs; and 5 more, see full page
Caution (28)
See full page: psychedex.org/substances/alpha-php
Not graded (3)
Not listed never means safe.

Seek help immediately if

  • Chest pain; racing, pounding, or irregular heartbeat
  • Very high body temperature; heavy sweating; hot, flushed skin
  • Severe agitation, paranoia, panic, or confusion
  • Severe headache; muscle rigidity or twitching
  • Seizures
  • Signs of stroke — face drooping, one-sided weakness, slurred speech
  • Difficulty breathing; collapse or unconsciousness

What to do

  1. Call emergency services for chest pain, overheating, seizure, or unresponsiveness
  2. Move them to a cool, quiet place and reduce stimulation
  3. Cool the body — remove excess clothing, apply cool damp cloths, fan them
  4. Keep them calm; reassure — panic worsens the cardiovascular strain
  5. If seizing, protect from injury (don't restrain); recovery position afterward
  6. Monitor breathing and be ready to give rescue breaths / CPR

Most stimulant overdoses settle with cooling, a calm environment, and time. The medical danger is hyperthermia, cardiac events (arrhythmia, heart attack, stroke), and seizures — get help immediately if any appear.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/alpha-php · Version r1 · Not medical adviceValues as of
On the printout