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Psychedex
Facts label

A-PVP Facts

Stimulant; Substituted cathinone; Dopamine reuptake inhibitor

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 2 mgLight2 – 5 mgCommon5 – 15 mgStrong15 – 25 mgHeavy25+ mg

Starts in 15 – 45 minLasts 2 – 6 hoursAfter-effects 2 – 8 hours

Also recorded: Smoked · Insufflated. See full page: psychedex.org/substances/a-pvp

Body and dependence

Acute toxicity
High
Chronic toxicity
Moderate
Physical dependence
Low
Psychological dependence
High
Withdrawal
Mild
Compulsive redosing
High

Tolerance

Builds
Rapid
Fully resets after
10 days
Carries over to
cocaine; amphetamine; methamphetamine; MDPV; methylphenidate

Effectslikely at a common dose

Perception
Dreaming suppression; +12 possible, including Spatial disorientation
Body
Stimulation; Restlessness; Vasoconstriction; Appetite suppression; Wakefulness; Insomnia; Physical fatigue; Pupil dilation; +27 possible, including Abnormal heartbeat, Excessive sweating, Heart rate perception changes
Thinking
Thought acceleration; Cognitive euphoria; Compulsive redosing urge; +28 possible, including Cognitive dysphoria, Decision impairment, Analysis suppression
Feeling
Euphoria; +10 possible, including Depression, Anxiety, Anhedonia
Self
Craving; +10 possible, including Compulsive repetitive behavior, Ego inflation, Social disconnection
Time
none likely · 3 possible, including Temporal disorientation
Awareness
none likely · 1 possible

Who shouldn't take it

Absolute
Coronary artery disease; Uncontrolled hypertension; Cardiac arrhythmias; Psychotic disorders; Bipolar disorder; Pregnancy and breastfeeding
Relative
Epilepsy; Chronic kidney disease

Combinations62 recorded

Lethal (2)
Ibogaine; Tramadol
Dangerous (29)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Benzodiazepines, Barbiturates; Ephedrine, Pseudoephedrine; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; SSRIs; Stimulants; Anticholinergics; Antipsychotics; Buspirone; Caffeine; Dopamine agonists; DXM; GHB, Baclofen; GHB, GBL; Ketamine, DXM, PCP; Lithium; NSAIDs; and 5 more, see full page
Caution (28)
See full page: psychedex.org/substances/a-pvp
Not graded (3)
Not listed never means safe.

Seek help immediately if

  • Chest pain; racing, pounding, or irregular heartbeat
  • Very high body temperature; heavy sweating; hot, flushed skin
  • Severe agitation, paranoia, panic, or confusion
  • Severe headache; muscle rigidity or twitching
  • Seizures
  • Signs of stroke — face drooping, one-sided weakness, slurred speech
  • Difficulty breathing; collapse or unconsciousness

What to do

  1. Call emergency services for chest pain, overheating, seizure, or unresponsiveness
  2. Move them to a cool, quiet place and reduce stimulation
  3. Cool the body — remove excess clothing, apply cool damp cloths, fan them
  4. Keep them calm; reassure — panic worsens the cardiovascular strain
  5. If seizing, protect from injury (don't restrain); recovery position afterward
  6. Monitor breathing and be ready to give rescue breaths / CPR

Most stimulant overdoses settle with cooling, a calm environment, and time. The medical danger is hyperthermia, cardiac events (arrhythmia, heart attack, stroke), and seizures — get help immediately if any appear.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/a-pvp · Version r1 · Not medical adviceValues as of
On the printout