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Psychedex
Facts label

7-Hydroxymitragynine Facts

Opioid; Indole alkaloid; Mu-opioid receptor agonist

Dose and durationby route · individual sensitivity varies

Oral

No dose recorded for this route. The timings are not a dose guide.

Starts in 20 – 45 minLasts 4 – 8 hoursAfter-effects 6 – 24 hours

Body and dependence

Acute toxicity
High
Chronic toxicity
Moderate
Physical dependence
High
Psychological dependence
High
Withdrawal
Severe · medical supervision
Compulsive redosing
High

Tolerance

Builds
Moderate
Fully resets after
Not recorded
Carries over to
morphine; mu-opioid agonists (class)

Effectslikely at a common dose

Perception
none likely · 4 possible, including Spatial disorientation, Visual acuity suppression, Visual haze / noise
Body
Body high; Muscle relaxation; Pain suppression; Pupil constriction; Sedation; +17 possible, including Nausea, Dizziness, Motor control impairment
Thinking
none likely · 12 possible, including Analysis suppression, Cognitive impairment, Compulsive redosing urge
Feeling
Euphoria; +2 possible
Self
none likely · 3 possible, including Craving, Social disconnection
Time
none likely · 2 possible, including Temporal disorientation
Awareness
none likely · 1 possible

Who shouldn't take it

Absolute
Concurrent CNS depressant use; Severe respiratory disease; Head injury with raised intracranial pressure; Severe hepatic impairment; Paralytic ileus
Relative
Active substance use disorder; Moderate hepatic impairment; Pregnancy; CYP3A4 inhibitor co-administration

Combinations60 recorded

Lethal (4)
Benzodiazepines, Barbiturates; GHB, Baclofen; GHB, GBL; Local anesthetics
Dangerous (28)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Anticholinergics; Antihistamines; Antipsychotics; Benzodiazepines; Buprenorphine, Kratom; Cannabis, THC; Clonidine, Guanfacine; Gabapentin, Pregabalin; MAOIs; MDMA, Amphetamines; MDMA, MDA; Naltrexone; NRIs; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids; THC; Caffeine; CBD; Glutamate modulator; Huperzine A; and 4 more, see full page
Caution (19)
See full page: psychedex.org/substances/7-hydroxymitragynine
Not graded (9)
Not listed never means safe.

Seek help immediately if

  • Unresponsive / can't be woken, even to a firm sternal rub
  • Slow, shallow, or stopped breathing
  • Pinpoint pupils
  • Blue/grey lips, fingertips, or skin (cyanosis)
  • Limp body; pale, clammy skin
  • Choking or gurgling sounds ("death rattle")
  • Slow, erratic, or absent pulse

What to do

  1. Try to wake them — shout their name, firm sternal rub
  2. Call emergency services immediately
  3. Administer naloxone if available
  4. Give rescue breaths (or CPR if there is no pulse)
  5. Place them in the recovery position
  6. Stay with them; re-dose naloxone every 2–3 minutes if there is no response
Reversal agent
Naloxone (Narcan) — opioid antagonist. May require repeated doses; its effect can wear off before the opioid does.

With prompt naloxone and rescue breathing, reversal is usually rapid. Because naloxone can wear off before the opioid — especially with long-acting opioids (methadone) or high-potency ones (fentanyl) — a period of monitoring is needed even after the person revives.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/7-hydroxymitragynine · Version r1.a2 · Not medical adviceValues as of
On the printout