7-Hydroxymitragynine

The 7-HMG experience is [[substance_class:psychoactive/opioid|opioid]] in character: a spreading [[glossary:warmth|warmth]] that blunts physical pain, quiets emotional tension, and slows both body and mind. Nothing is amplified or brightened — everything quiets. The experience is defined by what it removes. Compared to [[substance:morphine|morphine]], the [[effect:pain-suppression|analgesia]] and [[effect:euphoria|euphoria]] are qualitatively similar, arising from the same [[glossary:receptor-activation|receptor activation]]. Concentrated [[glossary:semi-synthetic|semi-synthetic]] 7-HMG products produce a faster and more intense version of the same state than traditional [[substance:kratom|kratom]] preparations. No [[substance_class:psychoactive/psychedelic|psychedelic]] or hallucinogenic features have been documented at any dose.

The 7-HMG experience is [[substance_class:psychoactive/opioid|opioid]] in character: a spreading [[glossary:warmth|warmth]] that blunts physical pain and quiets emotional [[glossary:distress|distress]], accompanied by heavy [[effect:sedation|sedation]] and a narrowing of mental activity. At lower exposures — typical of traditional [[substance:kratom|kratom]] use, where 7-HMG forms gradually via [[glossary:metabolism|liver metabolism]] — the onset is gentle, the sedation moderate, and mild [[effect:stimulation|stimulation]] may coexist with analgesic warmth. At higher exposures from concentrated [[glossary:semi-synthetic|semi-synthetic]] products, the opioid qualities dominate: deeper sedation, stronger [[effect:euphoria|euphoria]], and pronounced respiratory slowing. No [[substance_class:psychoactive/psychedelic|psychedelic]], [[substance_class:psychoactive/dissociative|dissociative]], or hallucinogenic features have been reported at any dose. [[glossary:set-and-setting|Set and setting]] modulate the experience less than they do for psychedelics — the pharmacology is the primary driver. Relative to [[substance:morphine|morphine]], 7-HMG produces qualitatively similar [[effect:pain-suppression|analgesia]] and euphoria through partial rather than full µ-opioid receptor [[glossary:receptor-activation|receptor activation]]. All human experiential data come from kratom preparations containing the full alkaloid mixture, not from isolated 7-HMG — the precise boundary between this compound''s contribution and that of co-administered kratom alkaloids remains undrawn.

===Forms & Identification=== 7-HMG products span a wide range of formats — [[glossary:sublingual]] films, pressed tablets, liquid tonics, and nasal sprays — each with different onset speeds and [[glossary:bioavailability]]. Sublingual and nasal routes bypass [[glossary:metabolism|liver metabolism]], delivering more compound to the bloodstream faster than oral routes{{cite|doi=10.1097/adm.0000000000001603|anchor=e87bfc23}}. This means two products containing the same milligram amount of 7-HMG can produce very different effects depending on the delivery format. Product labeling in this market is unreliable. Early [[substance:kratom]] products were documented with artificially elevated 7-HMG concentrations{{cite|doi=10.1007/s13181-016-0588-y|anchor=fe7c2e2b}}, and the current [[glossary:semi-synthetic]] market operates without standardized testing or manufacturing oversight{{cite|doi=10.1080/10826084.2025.2522162|anchor=bb917c8d}}. Stated doses on packaging should not be assumed accurate. ===Set & Setting=== The [[substance_class:psychoactive/opioid]] experience is less sensitive to [[glossary:set-and-setting]] than [[substance_class:psychoactive/psychedelic]] states, but environment still matters. A safe, comfortable location with a sober companion present reduces risk during initial exposures. Because 7-HMG depresses breathing — the primary lethal mechanism — falling asleep alone after use is a specific danger. This risk escalates sharply with any [[glossary:co-ingestion|co-ingested]] depressant. {{Guideline}} ==== Guidelines= === * '''Start with the lowest available dose''' and wait for full onset before considering [[glossary:redose|redosing]] — onset varies by route (sublingual and nasal are faster than oral) * '''Never combine with other depressants''' — [[substance:alcohol]], [[substance_class:chemical/benzodiazepine|benzodiazepines]], other opioids, and sleeping pills produce additive [[effect:respiratory-depression]] * '''Have naloxone available''' and ensure someone present knows how to administer it * '''Avoid using alone''', particularly with sublingual or nasal products that produce [[glossary:rapid-onset|rapid-onset]] effects * '''Do not drive or operate machinery''' — [[effect:sedation]] and impaired reaction time are core effects * '''Be aware of accumulation''' — 7-HMG's [[glossary:half-life]] extends from approximately 4.7 hours (single dose) to 24.7 hours with repeated use{{cite|doi=10.3390/molecules29050984|anchor=818f1103}}, meaning effects can stack unexpectedly with daily dosing * '''Avoid CYP3A4 inhibitors''' including [[glossary:grapefruit-juice|grapefruit]], which can unpredictably alter 7-HMG levels {{/Guideline}} {{Emergency}} ==== Emergency Response= === '''Recognizing an emergency:''' 7-HMG is an opioid — the emergency signs are [[glossary:opioid-overdose]] signs. Watch for: breathing that slows, becomes irregular, or stops; blue or gray lips and fingertips; pinpoint pupils; unresponsiveness to loud voice or sternal rub; gurgling or snoring sounds in an unconscious person. '''Immediate steps:''' * 1. Call emergency services immediately if breathing is slow, irregular, or absent * 2. Administer [[substance:naloxone]] if available — [[glossary:insufflation|intranasal]] or [[glossary:intramuscular]], per packaging instructions * 3. Place the person in the [[glossary:recovery-position]] (on their side) if unconscious but breathing * 4. Stay with them — naloxone wears off faster than 7-HMG, and breathing may stop again * 5. Do NOT induce [[effect:vomiting]] in an unconscious person * 6. Do NOT leave them alone to "sleep it off" '''What to tell the dispatcher:''' Name the substance (7-hydroxymitragynine or "7-OH" — a kratom-derived opioid), the amount if known, the time of [[glossary:ingestion]], and current symptoms. [[glossary:good-samaritan-law|Good Samaritan laws]] in many jurisdictions protect people who call for help during a [[glossary:drug-emergency]]. '''Reversal agent:''' Naloxone fully reverses 7-HMG respiratory depression{{cite|doi=10.1016/j.jpet.2025.103720|anchor=7b09bd9d}}. A second dose may be required because naloxone's [[glossary:duration-of-action]] is shorter than 7-HMG's. {{/Emergency}} {{Aftercare}} ==== Aftercare & Integration= === 7-HMG's extended half-life with repeated dosing{{cite|doi=10.3390/molecules29050984|anchor=1bd9806d}} means residual effects can persist longer than expected. Allow a full recovery period before driving, working, or making significant decisions. [[glossary:hydration]], light food, and rest support physical recovery. The opioid [[glossary:warmth]] and emotional quieting produced by 7-HMG can create a strong pull toward re-use, particularly for those managing chronic pain or emotional [[glossary:distress]]. Honest self-assessment of the desire to redose — especially if the interval between uses is shortening — is the single most important [[glossary:aftercare]] practice. {{/Aftercare}} {{Recovery}} ==== Recovery & Support= === 7-HMG produces classical opioid [[glossary:dependence]]. If you are using daily, experiencing [[glossary:withdrawal]] symptoms between doses, or escalating your dose, medical support is available. Published treatment approaches include [[substance:buprenorphine]]{{cite|doi=10.1097/adm.0000000000001685|anchor=77219c11}} and [[substance:methadone]]{{cite|doi=10.1097/adm.0000000000001666|anchor=4c42d27a}}, both established [[glossary:medication|medications]] for [[glossary:substance-use-disorder|opioid use disorder]]. Withdrawal from 7-HMG resembles opioid withdrawal broadly: muscle aches, [[effect:insomnia]], [[effect:anxiety]], [[effect:nausea]], sweating, and [[effect:restlessness]]. Medical management can substantially reduce discomfort{{cite|doi=10.1097/adm.0000000000001558|anchor=d6e8658c}}. If you are considering stopping, consult a healthcare provider experienced with opioid tapering — abrupt cessation after heavy [[glossary:chronic-use]] carries risk of severe withdrawal{{cite|doi=10.7759/cureus.105224|anchor=80fcc214}}. {{/Recovery}}

===Forms & Identification=== 7-HMG products come in several formats: [[glossary:sublingual]] films, pressed tablets, liquid tonics, and nasal sprays. Sublingual and nasal routes bypass [[glossary:metabolism|liver metabolism]], delivering more compound to the bloodstream faster than oral routes{{cite|doi=10.1097/adm.0000000000001603|anchor=ba38c5c3}}. Two products with the same milligram amount can produce very different effects depending on the delivery format. Product labeling is unreliable in this market. Early [[substance:kratom]] products were found with artificially elevated 7-HMG concentrations{{cite|doi=10.1007/s13181-016-0588-y|anchor=2d9c96e9}}, and the current [[glossary:semi-synthetic]] market has no standardized testing or manufacturing oversight{{cite|doi=10.1080/10826084.2025.2522162|anchor=4951d38f}}. Stated doses on packaging should not be assumed accurate. ===Set & Setting=== The [[substance_class:psychoactive/opioid]] experience is less sensitive to [[glossary:set-and-setting]] than [[substance_class:psychoactive/psychedelic|psychedelics]], but environment still matters. A safe location with a sober companion present reduces risk during initial exposures. Because 7-HMG suppresses breathing — the primary lethal mechanism — falling asleep alone after use is a specific danger, which escalates sharply with any [[glossary:co-ingestion|co-ingested]] depressant. {{Guideline}} ==== Guidelines= === * '''Start with the lowest available dose''' and wait for full onset before considering [[glossary:redose|redosing]] — onset varies by route (sublingual and nasal are faster than oral) * '''Never combine with other depressants''' — [[substance:alcohol]], [[substance_class:chemical/benzodiazepine|benzodiazepines]], other opioids, and sleeping pills produce additive [[effect:respiratory-depression]] * '''Have naloxone available''' and ensure someone present knows how to administer it * '''Avoid using alone''', particularly with sublingual or nasal products that produce [[glossary:rapid-onset|rapid-onset]] effects * '''Do not drive or operate machinery''' — [[effect:sedation]] and impaired reaction time are core effects * '''Be aware of accumulation''' — 7-HMG's [[glossary:half-life]] extends from approximately 4.7 hours (single dose) to 24.7 hours with repeated use{{cite|doi=10.3390/molecules29050984|anchor=d0319b8b}}, meaning effects can stack unexpectedly with daily dosing * '''Avoid CYP3A4 inhibitors''' including [[glossary:grapefruit-juice|grapefruit]], which can unpredictably alter 7-HMG levels {{/Guideline}} {{Emergency}} ==== Emergency Response= === '''Recognizing an emergency:''' 7-HMG is an opioid — the emergency signs are [[glossary:opioid-overdose]] signs. Watch for: breathing that slows, becomes irregular, or stops; blue or gray lips and fingertips; pinpoint pupils; unresponsiveness to loud voice or sternal rub; gurgling or snoring sounds in an unconscious person. '''Immediate steps:''' * 1. Call emergency services immediately if breathing is slow, irregular, or absent * 2. Administer [[substance:naloxone]] if available — [[glossary:insufflation|intranasal]] or [[glossary:intramuscular]], per packaging instructions * 3. Place the person in the [[glossary:recovery-position]] (on their side) if unconscious but breathing * 4. Stay with them — naloxone wears off faster than 7-HMG, and breathing may stop again * 5. Do NOT induce [[effect:vomiting]] in an unconscious person * 6. Do NOT leave them alone to "sleep it off" '''What to tell the dispatcher:''' Name the substance (7-hydroxymitragynine or "7-OH" — a kratom-derived opioid), the amount if known, the time of [[glossary:ingestion]], and current symptoms. [[glossary:good-samaritan-law|Good Samaritan laws]] in many jurisdictions protect people who call for help during a [[glossary:drug-emergency]]. '''Reversal agent:''' Naloxone fully reverses 7-HMG respiratory depression{{cite|doi=10.1016/j.jpet.2025.103720|anchor=08cfbad1}}. A second dose may be required because naloxone's [[glossary:duration-of-action]] is shorter than 7-HMG's. {{/Emergency}} {{Aftercare}} ==== Aftercare & Integration= === 7-HMG's extended half-life with repeated dosing{{cite|doi=10.3390/molecules29050984|anchor=52021da7}} means residual effects can persist longer than expected. Allow a full recovery period before driving, working, or making significant decisions. [[glossary:hydration]], light food, and rest support physical recovery. The opioid [[glossary:warmth]] and emotional quieting produced by 7-HMG can create a strong pull toward re-use, particularly for those managing chronic pain or emotional [[glossary:distress]]. Honest self-assessment of the desire to redose — especially if the interval between uses is shortening — is the single most important [[glossary:aftercare]] practice. {{/Aftercare}} {{Recovery}} ==== Recovery & Support= === 7-HMG produces classical opioid [[glossary:dependence]]. [[glossary:daily-use]], [[glossary:withdrawal]] symptoms between doses, or [[glossary:dose-escalation|escalating doses]] are signals that medical support is warranted. Treatment approaches include [[substance:buprenorphine]]{{cite|doi=10.1097/adm.0000000000001685|anchor=f840cc0a}} and [[substance:methadone]]{{cite|doi=10.1097/adm.0000000000001666|anchor=56f7376c}} — established [[glossary:medication|medications]] for [[glossary:substance-use-disorder|opioid use disorder]]. Withdrawal resembles opioid withdrawal broadly: muscle aches, [[effect:insomnia]], [[effect:anxiety]], [[effect:nausea]], sweating, and [[effect:restlessness]]. Medical management substantially reduces discomfort{{cite|doi=10.1097/adm.0000000000001558|anchor=66d5d75a}}. Abrupt cessation after heavy [[glossary:chronic-use]] carries risk of severe withdrawal{{cite|doi=10.7759/cureus.105224|anchor=a8d9adfa}} — consultation with a healthcare provider experienced in opioid tapering is the safer path. {{/Recovery}}

The experiential character of [[substance:7-hydroxymitragynine|7-hydroxymitragynine]] is [[substance_class:psychoactive/opioid|opioid]]-typical — [[glossary:warmth|warmth]], [[effect:pain-suppression|analgesia]], [[effect:anxiety-suppression|anxiolysis]], and [[effect:sedation|sedation]] predominate — but all human data derive from [[substance:kratom|kratom]] preparations containing the full alkaloid mixture, not isolated 7-HMG. [[glossary:route-of-administration|Route of administration]] substantially shapes the experience: oral kratom delivers 7-HMG gradually via hepatic metabolic conversion from [[substance:mitragynine|mitragynine]], while [[glossary:semi-synthetic|semi-synthetic]] [[glossary:sublingual|sublingual]] and nasal formulations bypass [[glossary:first-pass-metabolism|first-pass metabolism]], producing [[glossary:rapid-onset|rapid-onset]] effects at potentially greater [[glossary:intensity|intensity]]. No [[substance_class:psychoactive/psychedelic|psychedelic]], [[substance_class:psychoactive/dissociative|dissociative]], or hallucinogenic features have been documented at any dose. Relative to [[substance:morphine|morphine]], 7-HMG produces qualitatively similar analgesia and [[effect:euphoria|euphoria]] through partial rather than full [[glossary:mu-opioid-receptor|mu-opioid receptor]] agonism and G-protein-biased signaling. Its metabolic cascade — generating the even more potent mitragynine pseudoindoxyl in human [[glossary:plasma|plasma]] — and the absence of controlled human studies of isolated 7-HMG mean the precise experiential boundary between this compound and co-administered kratom alkaloids remains unresolved.