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Psychedex
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5F-AKB48 Facts

Cannabinoid; Indazolecarboxamide; Cannabinoid CB1 receptor full agonist

Dose and durationby route · individual sensitivity varies

Smoked(mg)
Threshold< 0.5 mgLight0.5 – 1 mgCommon1 – 2 mgStrong2 – 4 mgHeavy4+ mg

Starts in 0 – 20 minLasts 30 – 60 minAfter-effects 15 – 30 min

Body and dependence

Acute toxicity
High
Chronic toxicity
Moderate
Physical dependence
Moderate
Psychological dependence
Moderate
Withdrawal
Moderate
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
10.5 days
Carries over to
cannabis; synthetic cannabinoids

Effectslikely at a common dose

Perception
none likely · 4 possible, including Vestibular distortion, Spatial disorientation
Body
Body high; +17 possible, including Motor control impairment, Dizziness, Heart rate perception changes
Thinking
none likely · 18 possible, including Cognitive impairment, Analysis suppression, Decision impairment
Feeling
none likely · 7 possible, including Anxiety, Paranoia, Dysphoria
Self
none likely · 7 possible, including Communication suppression, Craving, Derealization
Time
none likely · 2 possible, including Temporal disorientation

Who shouldn't take it

Absolute
Long QT syndrome; Ischemic heart disease; Concurrent QT-prolonging medication use; Pregnancy and lactation
Relative
Seizure disorders; Psychotic disorders; Hepatic impairment; Chronic kidney disease

Combinations60 recorded

Dangerous (27)
Benzodiazepines, Barbiturates; GHB, Baclofen; GHB, GBL; Opioids; Alpha-2 adrenergic receptor antagonist; Atypical antipsychotics; Benzodiazepines; Caffeine; Cannabis; Cannabis, THC; Clonidine, Guanfacine; Ephedrine, Pseudoephedrine; Gabapentin, Pregabalin; Ketamine, DXM, PCP; Lithium; Local anesthetics; MAOIs; MDMA, MDA; NDRIs (Wellbutrin); Salvia, Ibogaine; SNRIs; SSRIs; THC; Buspirone; and 3 more, see full page
Caution (22)
See full page: psychedex.org/substances/5f-akb48
Not graded (11)
Not listed never means safe.

Seek help immediately if

Natural cannabis rarely causes a medical emergency — "greening out" is: pale/sweaty skin, dizziness, nausea or vomiting, anxiety or panic, rapid heartbeat, feeling faint — and usually passes with rest.

Seek emergency help for these — far more likely with synthetic cannabinoids ("spice" / K2):

  • Seizures
  • Severe chest pain; very fast or irregular heartbeat
  • Unresponsiveness or extreme drowsiness
  • Severe agitation, aggression, or psychosis
  • Repeated vomiting; difficulty breathing

What to do

  1. Sit or lie them down somewhere calm, cool, and quiet
  2. Reassure them — cannabis panic and "greening out" pass with time
  3. Offer sips of water; a little sugar can help if they feel faint
  4. Recovery position if nauseated, drowsy, or vomiting
  5. Stay with them and monitor
  6. For seizures, chest pain, unresponsiveness, or severe agitation, call emergency services

Natural cannabis "greening out" resolves with rest, calm, and time, with no lasting harm. Synthetic cannabinoids are unpredictable and can cause seizures, cardiac events, kidney injury, and severe agitation that needs emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/5f-akb48 · Version r1 · Not medical adviceValues as of
On the printout