5-MeO-MiPT Facts
Psychedelic;
Description
5-MeO-MiPT (5-methoxy-N-methyl-N-isopropyltryptamine) — Moxy — is a synthetic psychedelic of the tryptamine class. It activates serotonin receptors in the brain, producing psychedelic effects defined by unusual physical intensity.[1]
Subjective effects include physical stimulation, tactile enhancement, aphrodisiac warmth, empathogenic openness, and mild visual changes. The experience is defined by its body emphasis — a buzzing physical activation and emotional openness that sets it apart from the visually dominant character of most classical tryptamines.
5-MeO-MiPT does not produce physical dependence; tolerance builds rapidly after a single dose, limiting compulsive use.[2] The main acute danger is cardiovascular stress — documented as rapid heart rate and elevated blood pressure;[3] serotonergic drugs and stimulants sharply compound this risk.
Dose and durationby route · individual sensitivity varies
Starts in 10 – 40 minLasts 4 – 6 hoursAfter-effects 2 – 4 hours
Body and dependence
- Acute toxicity
- Low
- Chronic toxicity
- Moderate
- Physical dependence
- None
- Psychological dependence
- Low
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 7 days
- Carries over to
- LSD;
psilocybin; mescaline; DMT; 5-MeO-DMT; other serotonergic psychedelics
Effectslikely at a common dose
- Perception
- none likely · 26 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
- Body
- Stimulation;
Pupil dilation; +27 possible, including Muscle tension, Nausea, Vasoconstriction - Thinking
- none likely · 25 possible, including Memory suppression, Cognitive impairment, Confusion
- Feeling
- none likely · 7 possible, including Anxiety, Emotional lability
- Self
- none likely · 9 possible, including Depersonalization, Derealization
- Time
- none likely · 3 possible, including Temporal disorientation
- Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 3 possible
Who shouldn't take it
Combinations62 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Blough BE, Landavazo A, Decker AM, Partilla JS, Baumann MH, Rothman RB (2014) Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes. — Psychopharmacology doi:10.1007/s00213-014-3557-7
- [2]^de la Fuente Revenga M, Jaster AM, McGinn J, Silva G, Saha S, Gonzalez-Maeso J (2022) Tolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HT2A Receptor Agonists in Mice — ACS Chemical Neuroscience doi:10.1021/acschemneuro.2c00170
- [3]