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5-MeO-DiPT Facts

Psychedelic; Substituted tryptamine; Serotonin 2A receptor agonist

Description

5-MeO-DiPT (5-methoxy-N,N-diisopropyltryptamine) — Foxy, Foxy Methoxy — is a synthetic psychedelic of the tryptamine class. It blocks serotonin reuptake and directly activates serotonin receptors, producing a profile that blends psychedelic and empathogenic qualities.[1][2][3]

Subjective effects include tactile enhancement, auditory distortion, physical stimulation, euphoria, and heightened sexual arousal.[4] The experience is distinctly body-centered — more warmth and stimulation than visual immersion, closer to an empathogen than a classical psychedelic.

5-MeO-DiPT produces no physical dependence, and no lethal dose has been established — though animal studies document DNA damage and brain changes at high doses.[5][6] Combining it with MAOIs is potentially fatal: they block serotonin breakdown, and together with the drug's dual serotonergic action, the result can be dangerous overload.[7][8]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 3 mgLight3 – 10 mgCommon10 – 15 mgStrong15 – 20 mgHeavy20+ mg

Starts in 20 – 60 minLasts 3 – 8 hoursAfter-effects 2 – 6 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Moderate
Physical dependence
None
Psychological dependence
Low
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
psilocybin; LSD; DMT; mescaline; 5-MeO-DMT

Effectslikely at a common dose

Perception
none likely · 24 possible, including Spatial disorientation, Vestibular distortion
Body
Stimulation; Pupil dilation; Body high; +25 possible, including Diarrhea, Nausea, Muscle tension
Thinking
none likely · 19 possible, including Memory suppression, Cognitive impairment, Decision impairment
Feeling
none likely · 5 possible, including Emotional lability, Anxiety
Self
none likely · 7 possible, including Derealization
Time
none likely · 3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 1 possible

Who shouldn't take it

Absolute
Psychotic disorders; Bipolar disorder; Pregnancy and breastfeeding
Relative
Cardiovascular disease; Epilepsy; Prior 5-MeO-DiPT use with adverse psychiatric outcome; CYP2D6 poor metabolizer status

Combinations62 recorded

Lethal (2)
MAOIs; PCP
Dangerous (33)
Amphetamines; Atypical antipsychotics; Local anesthetics; MDMA, Amphetamines; MDMA, MDA; NRIs; Opioids; Stimulants; 5-HTP, Tryptophan; Alpha-2 adrenergic receptor antagonist; Anticholinergics; Antihistamines; Antipsychotics; Buspirone; Caffeine; Clonidine, Guanfacine; Dopamine agonists; DXM; Ephedrine, Pseudoephedrine; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; and 9 more, see full page
Caution (24)
See full page: psychedex.org/substances/5-meo-dipt
Not graded (3)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Hagino Y, Hall FS, Uhl GR, Sora I, Ikeda K (2021) Dual actions of 5-MeO-DIPT at the serotonin transporter and serotonin 5-HT1A receptor in the mouse striatum and prefrontal cortex. — Neuropsychopharmacology Reports doi:10.1002/npr2.12161
  2. [2]
    ^Fantegrossi WE, Harrington AW, Kiessel CL, Eckler JR, Rabin RA, Winter JC, Coop A, Rice KC, Woods JH (2006) Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. — Pharmacology, Biochemistry, and Behavior PMID:16460788
  3. [3]
    ^Li K, Li N, Chen Y, Li X, Qiao Y, Wang D, Di B, Xu P (2025) Effects of three tryptamines: alpha-methyltryptamine, 5-methoxy-alpha-methyltryptamine, and 5-methoxy-N,N-diisopropyltryptamine on acute toxicity, locomotor activity, and hallucinogenic behavior in mice. — Behavioural pharmacology doi:10.1097/fbp.0000000000000841
  4. [4]
    ^Malaca S, Lo Faro AF, Tamborra A, Pichini S, Busardò FP, Huestis MA (2020) Toxicology and Analysis of Psychoactive Tryptamines. — International journal of molecular sciences doi:10.3390/ijms21239279
  5. [5]
    ^Noworyta-Sokołowska K, Kamińska K, Kreiner G, Rogóż Z, Gołembiowska K (2016) Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats. — Neurotoxicity Research doi:10.1007/s12640-016-9654-0
  6. [6]
    ^Noworyta-Sokolowska K, Kaminska K, Rzemieniec J, Wnuk A, Wojcieszak J, Gorska AM, Kreiner G, Kajta M, Golembiowska K (2019) Effects of exposure to 5-MeO-DIPT during adolescence on brain neurotransmission and neurotoxicity in adult rats — Forensic Toxicology doi:10.1007/s11419-018-0433-x
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