5-MeO-DiBF Facts
Psychedelic;
Description
5-MeO-DiBF (5-methoxy-N,N-diisopropylbenzofuranethylamine) is a synthetic psychedelic of the benzofuran class. It activates serotonin receptors in the brain, producing the mild visual and tactile shifts characteristic of low-dose tryptamines.[1]
Subjective effects include mild visual enhancement, tactile enhancement, sexual arousal, and mood elevation.[2] The experience is defined by its body emphasis — sexual arousal and physical sensation dominate, while the cognitive and visual qualities remain subdued even at higher doses.
Physical dependence has not been documented; tolerance builds rapidly like other serotonergic psychedelics,[1] but the parent compound causes persistent brain DNA damage in rodents,[3] and whether 5-MeO-DiBF shares this risk is unknown. Combining it with monoamine oxidase inhibitors or tramadol can trigger dangerous overheating, muscle rigidity, and seizures.
Dose and durationby route · individual sensitivity varies
Starts in 30 – 45 minLasts 4 – 6 hoursAfter-effects 30 – 60 min
Body and dependence
- Acute toxicity
- Low
- Chronic toxicity
- Moderate
- Physical dependence
- None
- Psychological dependence
- Negligible
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 7 days
- Carries over to
- LSD;
psilocybin; mescaline; DMT; 5-MeO-DiPT
Effectslikely at a common dose
- Perception
- none likely · 32 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
- Body
- Pupil dilation;
Body scan awareness; +27 possible, including Nausea, Heart rate perception changes, Dizziness - Thinking
- none likely · 28 possible, including Memory suppression, Cognitive impairment, Suggestibility enhancement
- Feeling
- none likely · 9 possible, including Emotional lability, Anxiety, Paranoia
- Self
- none likely · 6 possible, including Derealization, Depersonalization
- Time
- none likely · 4 possible, including Temporal disorientation
- Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 3 possible
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^abFantegrossi WE, Harrington AW, Kiessel CL, Eckler JR, Rabin RA, Winter JC, Coop A, Rice KC, Woods JH (2006) Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. — Pharmacology, Biochemistry, and Behavior PMID:16460788
- [2]
- [3]^Noworyta-Sokołowska K, Kamińska K, Kreiner G, Rogóż Z, Gołembiowska K (2016) Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats. — Neurotoxicity Research doi:10.1007/s12640-016-9654-0