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5-MeO-DALT Facts

Psychedelic; Substituted tryptamine; Serotonin 2A receptor agonist

Description

5-MeO-DALT (5-methoxy-N,N-diallyltryptamine) — also known as Foxtrot — is a synthetic psychedelic of the tryptamine class. It activates serotonin receptors, but a second receptor pathway fires simultaneously and dampens the hallucinogenic response — making the experience more physical than visual.[1]

Subjective effects include euphoria, physical stimulation, sensory sharpening, wakefulness, and mild visual alterations.[2] The experience is predominantly physical — a buzzing, alert activation without the visual depth or introspective weight of psilocybin or DMT.[1]

No physical dependence has been documented, and no lethal dose has been established in any species.[3] Serious adverse events — delirium, muscle breakdown, and cyclic involuntary movements — appear in case reports, and combining it with MAOIs or other serotonin-raising drugs greatly amplifies risk.[4][5][6]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight8 – 12 mgCommon12 – 20 mgStrong20 – 30 mgHeavy35+ mg

Starts in 10 – 15 minLasts 2 – 4 hoursAfter-effects 1 – 3 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
LSD; psilocybin; mescaline; DMT; 5-MeO-DMT

Effectslikely at a common dose

Perception
none likely · 31 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
Body
Pupil dilation; +22 possible, including Dizziness, Heart rate perception changes, Nausea
Thinking
none likely · 27 possible, including Cognitive impairment, Decision impairment, Memory suppression
Feeling
none likely · 7 possible, including Anxiety, Emotional lability
Self
none likely · 8 possible, including Derealization, Depersonalization
Time
none likely · 3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 4 possible

Who shouldn't take it

Absolute
Bipolar disorder; Psychotic disorders; Pregnancy; Concurrent MAOI use
Relative
Cardiovascular disease; Epilepsy; Hepatic impairment; Concurrent serotonergic medication

Combinations62 recorded

Lethal (2)
MAOIs; PCP
Dangerous (19)
MDMA, MDA; Alpha-2 adrenergic receptor antagonist; Dopamine agonists; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); NRIs; Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/5-meo-dalt
Not graded (4)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^abKlein LM, Cozzi NV, Daley PF, Brandt SD, Halberstadt AL (2018) Receptor binding profiles and behavioral pharmacology of ring-substituted N,N-diallyltryptamine analogs — Neuropharmacology doi:10.1016/j.neuropharm.2018.02.028
  2. [2]
    ^PsychonautWiki contributors (2023) 5-MeO-DALT - PsychonautWiki Link
  3. [3]
    ^WHO Expert Committee on Drug Dependence (2020) 5-Methoxy-N,N-diallyltryptamine - WHO ECDD Repository Link
  4. [4]
    ^Jovel A, Felthous A, Bhattacharyya A (2014) Delirium due to intoxication from the novel synthetic tryptamine 5-MeO-DALT — Journal of Forensic Sciences doi:10.1111/1556-4029.12367
  5. [5]
    ^Kalasho A, Vibe Nielsen S (2016) 5-MeO-DALT; a novel designer drug on the market causing acute delirium and rhabdomyolysis — Acta Anaesthesiologica Scandinavica doi:10.1111/aas.12765
  6. [6]
    ^Thammongkolchai T, Termsarasab P, Alkhachroum A, Gujrati Y, Frucht SJ (2015) 5-Meo-DALT-induced Cyclic Myoclonus (P3.013) — Neurology (conference abstract) doi:10.1212/wnl.84.14_supplement.p3.013
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