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Psychedex
Facts label

5-APB Facts

Stimulant; Entactogen; Benzofuran; Serotonin releasing agent

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 20 mgLight25 – 50 mgCommon50 – 80 mgStrong80 – 100 mgHeavy100+ mg

Starts in 20 – 45 minLasts 5 – 8 hoursAfter-effects 12 – 72 hours

Body and dependence

Acute toxicity
High
Chronic toxicity
High
Physical dependence
Low
Psychological dependence
Moderate
Withdrawal
Mild
Compulsive redosing
Low

Tolerance

Builds
Moderate
Fully resets after
10 days
Carries over to
MDMA; MDA; 6-APB; 5-MAPB; 6-MAPB

Effectslikely at a common dose

Perception
Music enhancement; Touch enhancement; +9 possible
Body
Stimulation; Wakefulness; Appetite suppression; Body high; Body scan awareness; Pupil dilation; Spontaneous body sensations; Tactile euphoria; +19 possible, including Insomnia, Muscle tension, Bruxism
Thinking
Cognitive euphoria; Aesthetic enhancement; Introspection enhancement; Openness enhancement; +21 possible, including Compulsive redosing urge, Suggestibility enhancement
Feeling
Empathy enhancement; Emotional enhancement; Euphoria; +9 possible, including Depression, Anhedonia, Anxiety
Self
Communication enhancement; Disinhibition; Sociability enhancement; Social connection; Trust enhancement; +3 possible, including Craving
Time
Present-moment absorption; +1 possible
Transpersonal
none likely · 1 possible
Awareness
none likely · 3 possible

Who shouldn't take it

Absolute
Valvular heart disease; Cardiac arrhythmia; Psychotic disorders; Hepatic impairment; Pregnancy and breastfeeding; Concurrent MAOI therapy; Concurrent SSRI or SNRI therapy
Relative
Epilepsy

Combinations61 recorded

Lethal (2)
MAOIs; Tramadol
Dangerous (32)
Alpha-2 adrenergic receptor antagonist; Anticholinergics; Atypical antipsychotics; Caffeine; Dopamine agonists; Ephedrine, Pseudoephedrine; Local anesthetics; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; SNRIs; SSRIs; Stimulants; 5-HTP, Tryptophan; Antihistamines; Antipsychotics; Buspirone; Clonidine, Guanfacine; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; and 8 more, see full page
Caution (24)
See full page: psychedex.org/substances/5-apb
Not graded (3)
Not listed never means safe.

Seek help immediately if

  • Overheating / very high body temperature — heavy sweating, then hot dry skin (the leading cause of MDMA deaths, worse when dancing in hot venues)
  • Muscle rigidity, jaw clenching, tremor, or twitching (possible serotonin syndrome)
  • Fast, pounding heartbeat; chest pain
  • Agitation, confusion; seizures
  • Hyponatremia (water intoxication) — headache, confusion, drowsiness, vomiting, and seizures from drinking too much water
  • Nausea/vomiting; collapse or unconsciousness

What to do

  1. Move them somewhere cool and help them cool down — overheating is the main danger
  2. Sip water to stay hydrated but DO NOT overdrink — roughly a cup (250 ml) per hour if active; too much water can be deadly (hyponatremia)
  3. Get them to rest and stop dancing
  4. For overheating, seizures, chest pain, muscle rigidity/tremor, confusion, or unresponsiveness, call emergency services
  5. Recovery position if drowsy or vomiting; stay with them
  6. Be ready to give rescue breaths / CPR

Most resolve with cooling, rest, sensible hydration, and time. The life-threatening dangers are hyperthermia, serotonin syndrome, and hyponatremia (too much water) — each a medical emergency, not something to wait out.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/5-apb · Version r1 · Not medical adviceValues as of
On the printout