Fact Card
4-PrO-DMT
4-Propionyloxy-N,N-dimethyltryptamine
PsychedelicHallucinogenEntheogenSubstituted tryptamineTryptamineIndoleamineIndoleSerotonin 2A receptor agonistSerotonin receptor ligandSerotonin 2C receptor agonistSerotonin systemSerotonin 1A receptor partial agonist
Dosage
Most people feel effects in the 10 – 25 mg range. Always weigh your dose — never eyeball.
Oral
Light5 – 10 mg
Common10 – 25 mg
Strong25 – 45 mg
Heavy45 + mg
Duration
Effects typically last 4 – 8 hours. Onset and duration vary by route of administration.
Oral
Onset20 – 40 min
Total4 – 8 hours
Safety Profile
Based on available evidence, acute toxicity is rated low and chronic toxicity is rated low. The primary risks are psychological and contextual.
Acute toxicitylow
Chronic toxicitylow
Physical dep.none
Psychological dep.negligible
Compulsive redosingnegligible
Contraindications
There are 4 absolute contraindications — do not use this substance if any apply to you.
AbsoluteConcurrent lithium use with classic serotonergic psychedelics carries an alarmingly high seizure rate (47% of 62 analyzed reports). The mechanism remains unidentified. This is classified as an absolute contraindication for all psilocin-class compounds, including 4-PrO-DMT. Lamotrigine does not carry this risk (0/34 reports involved seizures), suggesting the interaction is lithium-specific rather than a general mood-stabilizer effect.
AbsoluteSerotonergic psychedelics potently activate 5-HT2A receptors on cortical pyramidal neurons, disrupting thalamocortical gating and increasing neural entropy. In individuals with latent or active psychotic vulnerability, this can precipitate prolonged psychotic episodes, mania, or exacerbation of existing symptoms. Risk extends to first-degree family history of these conditions. This is a class-level contraindication established for the psilocin/psilocybin pharmacological class and applied to 4-PrO-DMT by structural analogy as a psilocin prodrug.
6 more contraindications not shown — see the full record at psychedex.org/substances/4-pro-dmt
Psychedex · Fact Card · Not medical adviceData: Curiosity v1