4-AcO-MiPT Facts
Psychedelic;
Description
4-AcO-MiPT (4-acetoxy-N-methyl-N-isopropyltryptamine) — mipracetin — is a synthetic psychedelic of the tryptamine class. It activates serotonin receptors in the brain, producing the visual and cognitive shifts characteristic of classical psychedelics.[1]
Subjective effects include geometric visual patterns, synesthesia, music enhancement, heightened touch, emotional intensification, and euphoria. The experience is more sensory and erotically charged than psilocybin — strong visuals and body awareness without the heavy psychological weight.[2]
4-AcO-MiPT does not produce physical dependence, and no lethal dose data exist for any species. The dominant risk is psychological — panic and psychosis in vulnerable individuals — with a sharp escalation when combined with MAOIs or tramadol, which can trigger life-threatening serotonin overload.[3]
Dose and durationby route · individual sensitivity varies
Starts in 20 – 60 minLasts 4 – 8 hoursAfter-effects 2 – 4 hours
Body and dependence
- Acute toxicity
- Low
- Chronic toxicity
- Low
- Physical dependence
- None
- Psychological dependence
- Negligible
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 7 days
- Carries over to
- psilocybin;
psilocin; LSD; DMT; 4-AcO-DMT; mescaline
Effectslikely at a common dose
- Perception
- Geometry;
Color enhancement; +34 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion - Body
- Pupil dilation;
+26 possible, including Insomnia, Nausea, Dizziness - Thinking
- none likely · 28 possible, including Cognitive impairment, Decision impairment, Suggestibility enhancement
- Feeling
- none likely · 8 possible, including Emotional lability, Anxiety
- Self
- none likely · 9 possible, including Derealization, Depersonalization
- Time
- none likely · 4 possible, including Temporal disorientation
- Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 5 possible
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Kozell LB, Eshleman AJ, Swanson TL, Bloom SH, Wolfrum KM, et al. (2023) Pharmacologic Activity of Substituted Tryptamines at 5-HT2A, 5-HT2C, 5-HT1A Receptors and SERT — Journal of Pharmacology and Experimental Therapeutics doi:10.1124/jpet.122.001454
- [2]
- [3]^Malcolm B, Thomas K (2022) Serotonin toxicity of serotonergic psychedelics — Psychopharmacology doi:10.1007/s00213-021-05876-x