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4-AcO-DiPT Facts

Psychedelic; Substituted tryptamine; Serotonin 2A receptor agonist

Description

4-AcO-DiPT (4-acetoxy-N,N-diisopropyltryptamine) — Ipracetin, Aces — is a synthetic psychedelic of the tryptamine class. It activates serotonin receptors and serotonin transporters,[1][2] producing both psychedelic and empathogenic effects.

Subjective effects include visual distortion, mood elevation, empathogenic warmth, stimulation, and introspective depth. The experience is a compressed hybrid — intense psychedelic and empathogenic qualities packed into a few hours, more stimulating than 4-AcO-DMT and carrying an emotional warmth its close relatives lack.[3]

4-AcO-DiPT produces no physical dependence and carries low abuse liability.[4] The main danger is psychological — panic and distress that scale with dose — and combining it with MAOIs can trigger a potentially fatal serotonin overload; frequent use poses an unstudied cardiovascular risk.[1]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 3 mgLight5 – 15 mgCommon15 – 30 mgStrong30 – 45 mgHeavy45+ mg

Starts in 15 – 40 minLasts 3 – 4 hoursAfter-effects 2 – 6 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Moderate
Physical dependence
None
Psychological dependence
Low
Withdrawal
None recorded
Compulsive redosing
Low

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
psilocybin; psilocin; LSD; mescaline; 4-AcO-DMT; 4-HO-MET; 4-HO-MiPT

Effectslikely at a common dose

Perception
Touch enhancement; Visual drifting; Music enhancement; Color enhancement; Geometry; Visual breathing; +30 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
Body
Spontaneous body sensations; Pupil dilation; Body high; +30 possible, including Temperature dysregulation, Nausea, Insomnia
Thinking
Novelty enhancement; +34 possible, including Cognitive impairment, Decision impairment, Suggestibility enhancement
Feeling
none likely · 8 possible, including Emotional lability, Anxiety
Self
none likely · 10 possible, including Derealization, Depersonalization
Time
Time alteration; +2 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 5 possible

Who shouldn't take it

Absolute
Psychotic disorders; Pregnancy and breastfeeding; MAOI use; Lithium use
Relative
Valvular heart disease; Epilepsy; Bipolar disorder; CYP2D6 poor metabolizers

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (17)
Dopamine agonists; Lithium; MDMA, MDA; NRIs; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/4-aco-dipt
Not graded (6)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^abKelly TJ, Bonniwell EM, Mu L, Liu X, Hu Y, Friedman V, Yu H, Su W, McCorvy JD, Liu QS (2024) Psilocybin analog 4-OH-DiPT enhances fear extinction and GABAergic inhibition of principal neurons in the basolateral amygdala — Neuropsychopharmacology doi:10.1038/s41386-023-01744-8
  2. [2]
    ^Rickli A, Moning OD, Hoener MC, Liechti ME (2016) Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens — European Neuropsychopharmacology doi:10.1016/j.euroneuro.2016.05.001
  3. [3]
    ^Shulgin (1997) TiHKAL: Tryptamines I Have Known and Loved
  4. [4]
    ^Tittarelli R, Mannocchi G, Pantano F, Romolo FS (2015) Recreational use, analysis and toxicity of tryptamines. — Current neuropharmacology doi:10.2174/1570159x13666141210222409
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