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3-HO-PCE Facts

Dissociative; Arylcyclohexylamine; NMDA receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight5 – 10 mgCommon10 – 15 mgStrong15 – 25 mgHeavy25+ mg

Starts in 15 – 30 minLasts 4 – 6 hoursAfter-effects 2 – 6 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
Moderate
Psychological dependence
Moderate
Withdrawal
Mild
Compulsive redosing
High

Tolerance

Builds
Moderate
Fully resets after
10.5 days
Carries over to
ketamine; PCP; DXM; MXE; 3-HO-PCP; 3-MeO-PCE; O-PCE; nitrous oxide

Effectslikely at a common dose

Perception
none likely · 36 possible, including Vestibular distortion, Spatial disorientation, Visual haze / noise
Body
Nystagmus (eye wobbles); Sedation; Pain suppression; Motor control impairment; +30 possible, including Dizziness, Dehydration sensation, Nausea
Thinking
Cognitive impairment; +29 possible, including Confusion, Decision impairment, Information processing suppression
Feeling
none likely · 9 possible, including Paranoia, Anxiety, Depression
Self
none likely · 10 possible, including Depersonalization, Derealization, Communication suppression
Time
none likely · 3 possible, including Temporal disorientation
Awareness
none likely · 3 possible

Who shouldn't take it

Absolute
Respiratory compromise (COPD, sleep apnea); History of psychosis or schizophrenia; Pregnancy; Concurrent opioid use; Concurrent CNS depressant use (benzodiazepines, alcohol, GHB)
Relative
Cardiovascular disease; Seizure disorders; Hepatic impairment; Renal impairment

Combinations60 recorded

Lethal (4)
Benzodiazepines, Barbiturates; GHB, Baclofen; GHB, GBL; Local anesthetics
Dangerous (34)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Benzodiazepines; Buprenorphine, Kratom; Cannabis, THC; Gabapentin, Pregabalin; MDMA, Amphetamines; Naltrexone; NRIs; NSAIDs; Stimulants; THC; Anticholinergics; Antihistamines; Atypical antipsychotics; Buspirone; Caffeine; CBD; Clonidine, Guanfacine; Dopamine agonists; Glutamate modulator; Huperzine A; Ibogaine; Ketamine, DXM, PCP; and 10 more, see full page
Caution (18)
See full page: psychedex.org/substances/3-ho-pce
Not graded (4)
Not listed never means safe.

Seek help immediately if

  • Severe disorientation; unable to move or speak (deep dissociation / "k-hole")
  • Complete loss of coordination — cannot stand or walk safely
  • Vomiting while incapacitated (choking / aspiration risk)
  • Very high blood pressure; fast heart rate
  • Slow or shallow breathing at high doses (especially mixed with depressants)
  • Unconsciousness; rarely, seizures

What to do

  1. Move them somewhere safe, away from stairs, water, roads, and sharp edges — they cannot protect themselves
  2. Place in the recovery position if vomiting or unconscious (aspiration is a key risk)
  3. Stay with them and reassure calmly; keep the environment quiet
  4. If breathing is slow/shallow or they are unresponsive, call emergency services
  5. Do not let them wander; do not leave them alone
  6. Be ready to give rescue breaths / CPR

Effects wear off with time in a safe, monitored setting. The main dangers are physical injury and aspiration while incapacitated, and respiratory depression when combined with other depressants — not the dissociation itself.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/3-ho-pce · Version r1 · Not medical adviceValues as of
On the printout