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3-FPM Facts

Stimulant; Phenylmorpholine; Norepinephrine releasing agent

Description

3-FPM (3-fluorophenmetrazine) is a synthetic stimulant of the phenylmorpholine class. It forces dopamine and norepinephrine out of nerve terminals, producing stimulation and euphoria.[1]

Subjective effects include euphoria, increased energy, mental clarity, and psychomotor stimulation.[2] The experience is clean, moderate stimulation — closer to low-dose amphetamine than to serotonin-active compounds, without their emotional warmth.

3-FPM's dopamine potency rivals cocaine, creating real psychological dependence risk, and cardiovascular effects including rapid heart rate are the primary acute danger.[1][3] Mixing it with opioids or sedatives is the dominant risk: stimulant effects mask depressant overdose warning signs, and when 3-FPM wears off, breathing can fail suddenly.[4]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 10 mgLight15 – 30 mgCommon30 – 60 mgStrong60 – 90 mgHeavy90+ mg

Starts in 20 – 40 minLasts 4 – 6 hoursAfter-effects 4 – 12 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
Low
Psychological dependence
Moderate
Withdrawal
Mild
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
10 days
Carries over to
amphetamine; methamphetamine; phenmetrazine; cocaine; methylphenidate

Effectslikely at a common dose

Perception
none likely · 5 possible
Body
Stimulation; Appetite suppression; Pupil dilation; Wakefulness; +22 possible, including Insomnia, Vasoconstriction, Heart rate perception changes
Thinking
none likely · 15 possible, including Compulsive redosing urge
Feeling
none likely · 7 possible, including Anhedonia, Anxiety, Depression
Self
none likely · 7 possible, including Craving, Ego inflation
Time
none likely · 1 possible
Awareness
Sustained attention (vicara)

Who shouldn't take it

Absolute
Hypertension; Arrhythmias; Coronary artery disease; Peripheral vascular disease; Epilepsy; Psychotic disorders; Pregnancy; Concurrent MAOI use; Concurrent tramadol use
Relative
Renal impairment

Combinations61 recorded

Lethal (2)
MAOIs; Tramadol
Dangerous (26)
Anticholinergics; Caffeine; Ephedrine, Pseudoephedrine; GHB, Baclofen; Local anesthetics; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; SNRIs; SSRIs; Stimulants; 5-HTP, Tryptophan; Alpha-2 adrenergic receptor antagonist; Antipsychotics; Dopamine agonists; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; NSAIDs; Poppers (Alkyl nitrites); Poppers, Nitrates; and 2 more, see full page
Caution (30)
See full page: psychedex.org/substances/3-fpm
Not graded (3)
Not listed never means safe.

Seek help immediately if

  • Chest pain; racing, pounding, or irregular heartbeat
  • Very high body temperature; heavy sweating; hot, flushed skin
  • Severe agitation, paranoia, panic, or confusion
  • Severe headache; muscle rigidity or twitching
  • Seizures
  • Signs of stroke — face drooping, one-sided weakness, slurred speech
  • Difficulty breathing; collapse or unconsciousness

What to do

  1. Call emergency services for chest pain, overheating, seizure, or unresponsiveness
  2. Move them to a cool, quiet place and reduce stimulation
  3. Cool the body — remove excess clothing, apply cool damp cloths, fan them
  4. Keep them calm; reassure — panic worsens the cardiovascular strain
  5. If seizing, protect from injury (don't restrain); recovery position afterward
  6. Monitor breathing and be ready to give rescue breaths / CPR

Most stimulant overdoses settle with cooling, a calm environment, and time. The medical danger is hyperthermia, cardiac events (arrhythmia, heart attack, stroke), and seizures — get help immediately if any appear.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^abMayer FP, Burchardt NV, Decker AM, Partilla JS, Li Y, McLaughlin G, Kavanagh PV, Sandtner W, Blough BE, Brandt SD, Baumann MH, Sitte HH (2018) Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family — Neuropharmacology doi:10.1016/j.neuropharm.2017.10.006
  2. [2]
    ^WHO ECDD (2020) 3-fluorophenmetrazine - WHO Expert Committee on Drug Dependence Information Repository Link
  3. [3]
    ^Bäckberg M, Westerbergh J, Beck O, Helander A (2016) Adverse events related to the new psychoactive substance 3-fluorophenmetrazine - results from the Swedish STRIDA project — Clinical Toxicology doi:10.1080/15563650.2016.1211288
  4. [4]
    ^Ellefsen KN, Taylor EA, Simmons P, Willoughby V, Hall BJ (2017) Multiple Drug-Toxicity Involving Novel Psychoactive Substances, 3-Fluorophenmetrazine and U-47700 — Journal of Analytical Toxicology doi:10.1093/jat/bkx060
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