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Psychedex
Facts label

2M2B Facts

Depressant; Alcohol; GABA-A receptor positive allosteric modulator

Dose and durationby route · individual sensitivity varies

Oral(mL)
Threshold< 0.5 mLLight1 – 5 mLCommon5 – 10 mLStrong10 – 15 mLHeavy15+ mL

Starts in 15 – 30 minLasts 8 – 14 hoursAfter-effects 4 – 12 hours

Body and dependence

Acute toxicity
High
Chronic toxicity
Moderate
Physical dependence
Moderate
Psychological dependence
Moderate
Withdrawal
Severe · fatal · medical supervision
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
10 days
Carries over to
ethanol; benzodiazepines; barbiturates; neurosteroids; other GABA-A PAMs

Effectslikely at a common dose

Perception
none likely · 10 possible, including Spatial disorientation, Vestibular distortion, Visual acuity suppression
Body
Sedation; Motor control impairment; Muscle relaxation; +20 possible, including Dizziness, Nausea, Nystagmus (eye wobbles)
Thinking
Focus suppression; Memory suppression; Thought deceleration; Analysis suppression; Cognitive impairment; +14 possible, including Language suppression, Decision impairment, Information processing suppression
Feeling
Anxiety suppression; +4 possible, including Emotional lability
Self
Disinhibition; +9 possible, including Communication suppression, Craving, Ego inflation
Time
none likely · 2 possible, including Temporal disorientation

Who shouldn't take it

Absolute
Respiratory insufficiency; Concurrent CNS depressant use
Relative
Seizure disorder; History of alcohol or sedative dependence; Hepatic impairment; Pregnancy

Combinations60 recorded

Lethal (2)
GHB, GBL; Opioids
Dangerous (32)
Alpha-2 adrenergic receptor antagonist; Antipsychotics; Atypical antipsychotics; Benzodiazepines; Buprenorphine, Kratom; Cannabis, THC; Clonidine, Guanfacine; Gabapentin, Pregabalin; GHB, Baclofen; Naltrexone; NSAIDs; Stimulants; THC; Anticholinergics; Antihistamines; Dopamine agonists; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); and 8 more, see full page
Caution (20)
See full page: psychedex.org/substances/2m2b
Not graded (6)
Not listed never means safe.

Seek help immediately if

  • Extreme drowsiness — can't stay awake or be roused
  • Confusion, slurred speech, severe loss of coordination
  • Slow, shallow, or irregular breathing
  • Unconsciousness / unresponsive; limp, floppy body
  • Blue lips or fingertips
  • Vomiting while sedated (choking / aspiration risk)
  • Cold, clammy skin; weak pulse

What to do

  1. Try to wake them — shout, firm sternal rub
  2. If unresponsive or breathing is impaired, call emergency services
  3. Place them in the recovery position — critical, they can choke on vomit
  4. Monitor breathing continuously; be ready to give rescue breaths / CPR
  5. Never leave them alone to "sleep it off"
  6. Do not give other drugs, stimulants, or more depressants

Most depressant overdoses resolve with airway protection, breathing support, and monitoring. The danger is respiratory depression and choking on vomit — sharply worse when combined with opioids or alcohol. GHB/GBL overdoses often involve sudden deep unconsciousness and may self-resolve, but airway protection is essential.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/2m2b · Version r1 · Not medical adviceValues as of
On the printout