2C-T Facts
Psychedelic;
Description
2C-T (2,5-dimethoxy-4-methylthiophenethylamine) — also known as Tesseract — is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors, disrupting normal sensory filtering and producing a mild psychedelic state.[1]
Subjective effects include tactile sensitivity, introspection, mild visual distortion, and sedation. The character is quiet and inward — closer to contemplation than perceptual fireworks, described as "stoning" rather than stimulating.[2]
2C-T produces no physical dependence, and no death has been specifically attributed to the compound. The main danger is combining it with monoamine oxidase inhibitors — drugs that slow its breakdown — which can intensify effects sharply and trigger a dangerous overheating and seizure response.[3]
Dose and durationby route · individual sensitivity varies
Starts in 30 – 45 minLasts 3 – 6 hoursAfter-effects 1 – 2 hours
Body and dependence
- Acute toxicity
- Low
- Chronic toxicity
- Negligible
- Physical dependence
- None
- Psychological dependence
- Negligible
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 7 days
- Carries over to
- LSD;
psilocybin; mescaline; DMT
Effectslikely at a common dose
- Perception
- Geometry;
Color enhancement; Visual drifting; Color alteration; +28 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise - Body
- Pupil dilation;
+25 possible, including Nausea, Vasoconstriction, Insomnia - Thinking
- Novelty enhancement;
+31 possible, including Memory suppression, Cognitive impairment, Decision impairment - Feeling
- Emotional enhancement;
+7 possible, including Anxiety, Emotional lability, Paranoia - Self
- none likely · 9 possible, including Derealization, Depersonalization
- Time
- Time alteration;
+2 possible, including Temporal disorientation - Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 4 possible
Who shouldn't take it
Combinations60 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Halberstadt AL, Luethi D, Hoener MC, Trachsel D, Brandt SD, Liechti ME (2023) Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines — Psychopharmacology doi:10.1007/s00213-022-06279-2
- [2]
- [3]^Rached G, Campana A, Fiani D, et al. (2026) Safety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances — CNS Drugs doi:10.1007/s40263-025-01256-7