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2C-T-2 Facts

Psychedelic; Substituted phenethylamine; Serotonin 2A receptor agonist

Description

2C-T-2 (2,5-dimethoxy-4-ethylthiophenethylamine) is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors in the brain, producing the visual, emotional, and cognitive shifts of classical psychedelic experience.[1]

Subjective effects include geometric visual patterns, emotional intensification, introspective depth, time alteration, and heightened sensory richness. The experience is more emotionally textured and introspective than 2C-B — richly layered rather than primarily visual, with a heavy physical undertone.

2C-T-2 produces no physical dependence, and no lethal dose has been established.[2] The main danger is a drug interaction: monoamine oxidase enzymes break down the compound,[3] so MAO inhibitors block clearance and allow serotonin to reach potentially fatal levels.

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 3 mgLight5 – 12 mgCommon12 – 20 mgStrong20 – 25 mgHeavy25+ mg

Starts in 20 – 45 minLasts 6 – 8 hoursAfter-effects 2 – 4 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
LSD; psilocybin; mescaline; DMT; 2C-B; 2C-E; 2C-T-7; DOx series

Effectslikely at a common dose

Perception
Color alteration; +35 possible, including Spatial disorientation, Visual haze / noise, Double vision
Body
Pupil dilation; Body scan awareness; +32 possible, including Nausea, Vasoconstriction, Dizziness
Thinking
none likely · 32 possible, including Memory suppression, Thought loops, Confusion
Feeling
none likely · 9 possible, including Emotional lability, Anxiety, Paranoia
Self
none likely · 9 possible, including Derealization, Depersonalization
Time
none likely · 3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 4 possible

Who shouldn't take it

Absolute
Psychotic disorders; Pregnancy; MAO inhibitor therapy; Lithium therapy
Relative
Cardiovascular disease; Epilepsy; Bipolar disorder

Combinations60 recorded

Lethal (6)
Amphetamines; MDMA, Amphetamines; MDMA, MDA; Psychedelics; SNRIs; Stimulants
Dangerous (29)
5-HTP, Tryptophan; Alpha-2 adrenergic receptor antagonist; Ephedrine, Pseudoephedrine; Local anesthetics; NRIs; Opioids; Antihistamines; Antipsychotics; Benzodiazepines, Barbiturates; Buspirone; Caffeine; Cannabis; Clonidine, Guanfacine; Dopamine agonists; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; L-Tyrosine; Lithium; Naltrexone; NDRIs (Wellbutrin); NSAIDs; and 5 more, see full page
Caution (21)
See full page: psychedex.org/substances/2c-t-2
Not graded (4)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Luethi D, Trachsel D, Hoener MC, Liechti ME (2018) Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs) — Neuropharmacology doi:10.1016/j.neuropharm.2017.07.012
  2. [2]
    ^Dean BV, Stellpflug SJ, Burnett A, Engebretsen KM (2013) 2C or Not 2C: Phenethylamine Designer Drug Review — Journal of Medical Toxicology doi:10.1007/s13181-013-0295-x
  3. [3]
    ^Theobald DS, Maurer HH (2007) Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series) — Biochemical Pharmacology doi:10.1016/j.bcp.2006.09.033
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