2C-C Facts
Psychedelic;
Description
2C-C (2,5-dimethoxy-4-chlorophenethylamine) is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors in the brain, producing perceptual distortion with an unusually quiet, sedating character.
Subjective effects include geometric visual patterns, color enhancement, empathogenic warmth, sedation, and a pervasive calm. The experience is defined by stillness — a gentle, contemplative drift with soft visual overlay rather than the stimulating push typical of most 2C analogs.
2C-C does not produce physical dependence, and no human death has been attributed to it alone — though animal studies found neurotoxic effects and signs of abuse potential at high doses.[1] Combining it with MAOIs or tramadol risks a dangerous serotonin overload — fever, muscle rigidity, altered consciousness — that can be life-threatening.
Dose and durationby route · individual sensitivity varies
Starts in 20 – 45 minLasts 4 – 8 hoursAfter-effects 2 – 6 hours
Body and dependence
- Acute toxicity
- Low
- Chronic toxicity
- Moderate
- Physical dependence
- None
- Psychological dependence
- Low
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 14 days
- Carries over to
- 2C-B;
2C-I; 2C-E; LSD; psilocybin; DMT; mescaline; DOI
Effectslikely at a common dose
- Perception
- Color alteration;
Color enhancement; +25 possible, including Visual haze / noise, Spatial disorientation - Body
- Pupil dilation;
+24 possible, including Nausea, Heart rate perception changes, Muscle tension - Thinking
- none likely · 26 possible, including Memory suppression, Decision impairment, Suggestibility enhancement
- Feeling
- none likely · 7 possible, including Emotional lability, Anxiety
- Self
- none likely · 7 possible, including Derealization
- Time
- none likely · 3 possible, including Temporal disorientation
- Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 3 possible
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
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References
- [1]^Kim YJ, Ma SX, Hur KH, Lee Y, Ko YH, Lee BR, Kim SK, Sung SJ, Kim KM, Kim HC, Lee SY, Jang CG (2021) New designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rodents. — Archives of Toxicology doi:10.1007/s00204-021-02980-x