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25I-NBOMe Facts

Psychedelic; Substituted phenethylamine; Serotonin 2A receptor agonist

Description

25I-NBOMe — N-Bomb, Smiles — is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors in the brain, disrupting normal sensory filtering and producing the visual and cognitive shifts characteristic of psychedelics.[1]

Subjective effects include geometric visual patterns, color enhancement, synesthesia, euphoria, and accelerated thinking. The experience is defined by a heavy physical load — vasoconstriction, racing heart, and temperature dysregulation accompany the visuals at virtually every active dose, distinguishing it sharply from LSD and other classical psychedelics.

25I-NBOMe does not produce physical dependence, but it carries critical acute toxicity risk — the margin between a psychoactive and potentially lethal dose is extremely narrow.[2] Multiple analytically confirmed deaths have involved seizures, dangerous overheating, muscle breakdown, and organ failure, and no dose can be considered reliably safe.[3]

Dose and durationby route · individual sensitivity varies

Sublingual(µg)
Threshold< 50 µgLight200 – 500 µgCommon500 – 700 µgStrong700 – 1000 µgHeavy1000+ µg

Starts in 15 – 120 minLasts 6 – 10 hoursAfter-effects 3 – 6 days

Body and dependence

Acute toxicity
Critical
Chronic toxicity
Moderate
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Low

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
LSD; psilocybin; psilocin; DMT; mescaline; 2C-I; 2C-B; 25C-NBOMe; 25B-NBOMe

Effectslikely at a common dose

Perception
Color enhancement; Visual drifting; Color alteration; Tracers; Symmetrical texture repetition; Brightness alteration; Environmental patterning; Geometry; Visual breathing; Visual morphing; +22 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
Body
Stimulation; Vasoconstriction; Pupil dilation; Wakefulness; Spontaneous body sensations; Body high; +28 possible, including Muscle tension, Insomnia, Dehydration sensation
Thinking
Pattern recognition enhancement; Novelty enhancement; Aesthetic enhancement; Thought connectivity; +28 possible, including Cognitive impairment, Suggestibility enhancement, Memory suppression
Feeling
Emotional enhancement; +9 possible, including Anxiety, Emotional lability, Dysphoria
Self
none likely · 9 possible, including Derealization, Depersonalization, Communication suppression
Time
Time alteration; +4 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 3 possible

Who shouldn't take it

Absolute
Cardiovascular disease; Epilepsy; Psychotic disorders; Bipolar disorder; Pregnancy; Concurrent serotonergic medications
Relative
Hepatic impairment; Concurrent CYP2D6/CYP3A4 inhibitors

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (18)
MDMA, MDA; NRIs; Buspirone; Dopamine agonists; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/25i-nbome
Not graded (5)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Zawilska JB, Kacela M, Adamowicz P (2020) NBOMes-Highly Potent and Toxic Alternatives of LSD — Frontiers in Neuroscience doi:10.3389/fnins.2020.00078
  2. [2]
    ^Halberstadt AL (2017) Pharmacology and Toxicology of N-Benzylphenethylamine (NBOMe) Hallucinogens — Current Topics in Behavioral Neurosciences doi:10.1007/7854_2016_64
  3. [3]
    ^Nichols DE, Grob CS (2018) Is LSD toxic? — Forensic Science International doi:10.1016/j.forsciint.2018.01.006
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