25I-NBOH Facts
Psychedelic;
Description
25I-NBOH is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors in the brain, producing the visual and cognitive shifts characteristic of classical psychedelics.
Subjective effects include geometric visual patterns, color enhancement, thought acceleration, emotional enhancement, and sustained physical stimulation. The experience is defined by its body weight — vasoconstriction, elevated heart rate, and temperature instability form a persistent physical backdrop absent from psilocybin or DMT.
25I-NBOH produces no physical dependence, but no lethal dose or safety margin has been established for any species. The main danger is a narrow, uncharacterized gap between common and dangerous doses, compounded by unreliable product identity on unregulated markets.[1]
Dose and durationby route · individual sensitivity varies
Starts in 15 – 60 minLasts 5 – 8 hoursAfter-effects 3 – 12 days
Body and dependence
- Acute toxicity
- Moderate
- Chronic toxicity
- Moderate
- Physical dependence
- None
- Psychological dependence
- Negligible
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 14 days
- Carries over to
- LSD;
psilocybin; mescaline; 25I-NBOMe; 25CN-NBOH; other NBOH compounds; other serotonergic psychedelics
Effectslikely at a common dose
- Perception
- Color enhancement;
Visual drifting; Color alteration; Music enhancement; Geometry; Visual breathing; +30 possible, including Visual haze / noise, Spatial disorientation, Vestibular distortion - Body
- Stimulation;
Pupil dilation; Wakefulness; Body high; +28 possible, including Temperature dysregulation, Vasoconstriction, Heart rate perception changes - Thinking
- Aesthetic enhancement;
+27 possible, including Cognitive impairment, Decision impairment, Suggestibility enhancement - Feeling
- none likely · 7 possible, including Emotional lability, Anxiety
- Self
- none likely · 9 possible, including Derealization, Depersonalization
- Time
- Time alteration;
+4 possible, including Temporal disorientation - Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 4 possible
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Pelletier R, Gicquel T, Carvelli J, Balaz P, Pelissier-Alicot AL, Morel I, Bottinelli C, Solas C, Le Dare B, Fabresse N (2024) Severe 25E-NBOH intoxication associated with MDPHP intake: a case report, metabolism study, and literature review — International Journal of Legal Medicine doi:10.1007/s00414-023-03151-6