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25E-NBOH Facts

Psychedelic; Substituted phenethylamine; Serotonin 2A receptor agonist

Description

25E-NBOH (2C-E-NBOH) is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors in the brain,[1] producing the visual distortions and cognitive shifts characteristic of classical psychedelics.

Subjective effects include geometric visual patterns, brightened colors, cognitive stimulation, analytical clarity, and heightened verbal fluency. The experience is unusually lucid — perception becomes dramatically altered while the capacity to think and speak stays largely intact, distinguishing it from the cognitive dissolution characteristic of high-dose tryptamines.

25E-NBOH does not produce physical dependence, but its toxic dose in humans is unknown, and at least one source references fatal cases.[2] The primary dangers are cardiovascular: blood vessel constriction can drive dangerous blood pressure elevation, and the class carries documented risk of seizures and fatal overheating.[3]

Dose and durationby route · individual sensitivity varies

Sublingual(µg)
Threshold< 50 µgLight200 – 600 µgCommon600 – 1000 µgStrong1000 – 1500 µgHeavy1500+ µg

Starts in 15 – 45 minLasts 4 – 6 hoursAfter-effects 2 – 6 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
LSD; psilocybin; mescaline; DMT; DOx series; 25x-NBOMe compounds; 25x-NBOH compounds

Effectslikely at a common dose

Perception
Color enhancement; Visual drifting; Color alteration; Geometry; Visual breathing; +28 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
Body
Pupil dilation; Body scan awareness; +31 possible, including Vasoconstriction, Muscle tension, Temperature dysregulation
Thinking
none likely · 34 possible, including Memory suppression, Cognitive impairment, Decision impairment
Feeling
none likely · 8 possible, including Emotional lability, Anxiety, Paranoia
Self
none likely · 10 possible, including Derealization, Depersonalization
Time
Time alteration; +4 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 5 possible

Who shouldn't take it

Absolute
Cardiovascular disease; Seizure disorders; MAOI use
Relative
Concurrent stimulant use; Seizure-threshold-lowering agents; Psychotic disorders; Pregnancy; Lithium

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (18)
MDMA, MDA; NRIs; Buspirone; Dopamine agonists; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/25e-nboh
Not graded (5)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Munir DD, Shetty RA, Gatch MB, Sumien N, Hill RD, Priddy JA, Forster MJ (2025) Locomotor and discriminative stimulus effects of NBOH hallucinogens in rodents — Behavioural Pharmacology doi:10.1097/fbp.0000000000000802
  2. [2]
    ^Xiang J, Wen D, Zhai W, Zhao J, Xiang P, Ma C, Shi Y (2024) Metabolic characterization of 25X-NBOH and 25X-NBOMe phenethylamines based on UHPLC-Q-Exactive Orbitrap MS in human liver microsomes. — Journal of Pharmaceutical and Biomedical Analysis doi:10.1016/j.jpba.2024.116020
  3. [3]
    ^Halberstadt AL (2017) Pharmacology and Toxicology of N-Benzylphenethylamine (NBOMe) Hallucinogens — Current Topics in Behavioral Neurosciences doi:10.1007/7854_2016_64
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