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Psychedex
Facts label

2-Fluorodeschloroketamine Facts

Dissociative; Arylcyclohexylamine; NMDA receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight10 – 25 mgCommon25 – 70 mgStrong70 – 100 mgHeavy100+ mg

Starts in 15 – 50 minLasts 2.5 – 5 hoursAfter-effects 2 – 4 hours

Also recorded: Insufflated. See full page: psychedex.org/substances/2-fluorodeschloroketamine

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
Low
Psychological dependence
Moderate
Withdrawal
Mild
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
10 days
Carries over to
ketamine; deschloroketamine; methoxetamine; phencyclidine

Effectslikely at a common dose

Perception
Spatial disorientation; Ganzfeld effect; +21 possible, including Visual acuity suppression, Double vision, Vestibular distortion
Body
Motor control impairment; Pain suppression; +26 possible, including Dizziness, Nystagmus (eye wobbles), Heart rate perception changes
Thinking
Cognitive impairment; +25 possible, including Memory suppression, Decision impairment, Analysis suppression
Feeling
none likely · 6 possible, including Anxiety, Emotional lability, Paranoia
Self
Derealization; +8 possible, including Depersonalization, Communication suppression, Social disconnection
Time
Time alteration; +3 possible, including Temporal disorientation
Awareness
none likely · 2 possible

Who shouldn't take it

Absolute
Hypertension; Coronary artery disease; Respiratory compromise; Psychotic disorders; Pregnancy and breastfeeding; Concurrent CNS depressant use
Relative
Epilepsy; Urological conditions

Combinations63 recorded

Lethal (4)
Alcohol; GHB, GBL; Ibogaine; Tramadol
Dangerous (34)
Amphetamines; Antihistamines; Benzodiazepines; Benzodiazepines, Barbiturates; Buprenorphine, Kratom; Ephedrine, Pseudoephedrine; Naltrexone; NDRIs (Wellbutrin); NRIs; NSAIDs; Opioids; Stimulants; THC; Anticholinergics; Antipsychotics; Buspirone; Caffeine; Clonidine, Guanfacine; Dopamine agonists; Gabapentin, Pregabalin; GHB, Baclofen; Ketamine, DXM, PCP; Lithium; Local anesthetics; and 10 more, see full page
Caution (21)
See full page: psychedex.org/substances/2-fluorodeschloroketamine
Not graded (4)
Not listed never means safe.

Seek help immediately if

  • Severe disorientation; unable to move or speak (deep dissociation / "k-hole")
  • Complete loss of coordination — cannot stand or walk safely
  • Vomiting while incapacitated (choking / aspiration risk)
  • Very high blood pressure; fast heart rate
  • Slow or shallow breathing at high doses (especially mixed with depressants)
  • Unconsciousness; rarely, seizures

What to do

  1. Move them somewhere safe, away from stairs, water, roads, and sharp edges — they cannot protect themselves
  2. Place in the recovery position if vomiting or unconscious (aspiration is a key risk)
  3. Stay with them and reassure calmly; keep the environment quiet
  4. If breathing is slow/shallow or they are unresponsive, call emergency services
  5. Do not let them wander; do not leave them alone
  6. Be ready to give rescue breaths / CPR

Effects wear off with time in a safe, monitored setting. The main dangers are physical injury and aspiration while incapacitated, and respiratory depression when combined with other depressants — not the dissociation itself.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/2-fluorodeschloroketamine · Version r1 · Not medical adviceValues as of
On the printout