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2-FEA Facts

Stimulant; Substituted amphetamine; Monoamine releasing agent

Description

2-FEA (2-fluoroethamphetamine) is a synthetic stimulant of the substituted amphetamine class. It floods the brain with dopamine and norepinephrine, producing the stimulant euphoria and arousal common to the amphetamine family.[1]

Subjective effects include cognitive euphoria, increased focus, wakefulness, and mild empathogenic warmth.[2] The experience is a compressed stimulant arc with a subtle serotonin-driven warmth — more sociable than 2-FMA, but nothing like the emotional depth of 3-FEA.

2-FEA carries moderate dependence risk and meaningful cardiovascular toxicity.[3][4] Blood pressure elevation is the primary acute danger: related fluorinated amphetamines have caused heart attacks and brain hemorrhage,[5] and combining 2-FEA with serotonin-affecting drugs risks a life-threatening overheating response.

Dose and durationby route · individual sensitivity varies

Insufflated(mg)
Threshold< 15 mgLight20 – 30 mgCommon30 – 40 mgStrong40 – 60 mgHeavy60+ mg

Starts in 5 – 15 minLasts 1 – 2.5 hoursAfter-effects 1 – 3 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
Moderate
Psychological dependence
Moderate
Withdrawal
Mild
Compulsive redosing
High

Tolerance

Builds
Moderate
Fully resets after
10.5 days
Carries over to
amphetamine; methamphetamine; 2-FA; 2-FMA; other dopamine-releasing stimulants

Effectslikely at a common dose

Perception
none likely · 3 possible
Body
Stimulation; Appetite suppression; Dry mouth; Pupil dilation; Vasoconstriction; Wakefulness; +19 possible, including Abnormal heartbeat, Excessive sweating, Insomnia
Thinking
Thought acceleration; +15 possible, including Compulsive redosing urge
Feeling
none likely · 8 possible, including Anxiety, Depression, Anhedonia
Self
none likely · 6 possible, including Craving, Ego inflation
Time
none likely · 2 possible
Awareness
none likely · 1 possible

Who shouldn't take it

Absolute
Cardiovascular disease; Pregnancy and lactation; Concurrent MAOI therapy
Relative
Seizure disorders; Psychotic disorders, severe anxiety, bipolar disorder; Hyperthyroidism; Concurrent serotonergic medication

Combinations63 recorded

Lethal (4)
Cocaine; MAOIs; MDMA; Tramadol
Dangerous (28)
Alpha-2 adrenergic receptor antagonist; Anticholinergics; Caffeine; Ephedrine, Pseudoephedrine; GHB, Baclofen; Local anesthetics; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; SNRIs; SSRIs; Stimulants; 5-HTP, Tryptophan; Antipsychotics; Buspirone; Dopamine agonists; DXM; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; NSAIDs; and 4 more, see full page
Caution (28)
See full page: psychedex.org/substances/2-fea
Not graded (3)
Not listed never means safe.

Seek help immediately if

  • Chest pain; racing, pounding, or irregular heartbeat
  • Very high body temperature; heavy sweating; hot, flushed skin
  • Severe agitation, paranoia, panic, or confusion
  • Severe headache; muscle rigidity or twitching
  • Seizures
  • Signs of stroke — face drooping, one-sided weakness, slurred speech
  • Difficulty breathing; collapse or unconsciousness

What to do

  1. Call emergency services for chest pain, overheating, seizure, or unresponsiveness
  2. Move them to a cool, quiet place and reduce stimulation
  3. Cool the body — remove excess clothing, apply cool damp cloths, fan them
  4. Keep them calm; reassure — panic worsens the cardiovascular strain
  5. If seizing, protect from injury (don't restrain); recovery position afterward
  6. Monitor breathing and be ready to give rescue breaths / CPR

Most stimulant overdoses settle with cooling, a calm environment, and time. The medical danger is hyperthermia, cardiac events (arrhythmia, heart attack, stroke), and seizures — get help immediately if any appear.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Simmler LD, Liechti ME (2018) Pharmacology of MDMA- and Amphetamine-Like New Psychoactive Substances — Handbook of Experimental Pharmacology doi:10.1007/164_2018_113
  2. [2]
    ^(2024) 2-FEA - PsychonautWiki Link
  3. [3]
    ^Rothman RB, Baumann MH (2006) Therapeutic potential of monoamine transporter substrates — Current Topics in Medicinal Chemistry PMID:17017961
  4. [4]
    ^Annawald K, Streckfuss-Bomeke K, Meyer T (2024) Methamphetamine-induced cardiotoxicity: in search of protective transcriptional mechanisms — Herz doi:10.1007/s00059-024-05279-6
  5. [5]
    ^Gresnigt FMJ, Snik A, Franssen EJF, Vanhommerig JW, de Lange DW, Riezebos RK (2022) 4-Fluoroamphetamine (4-FA) intoxication results in exaggerated blood pressure effects compared to MDMA and amphetamine: A retrospective analysis — Journal of the American College of Emergency Physicians Open doi:10.1002/emp2.12813
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