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1V-LSD Facts

Psychedelic; Lysergamide; Serotonin 2A receptor agonist

Description

1V-LSD (1-valeroyl-lysergic acid diethylamide) — also known as Valerie — is a synthetic psychedelic of the lysergamide class. Once converted, it activates serotonin receptors in the brain, producing the visual and cognitive shifts characteristic of classical psychedelics.[1]

Subjective effects include geometric visual patterns, color enhancement, time alteration, thought acceleration, and ego dissolution. The experience mirrors LSD — a long-arc, all-encompassing shift in perception and emotion with a characteristic electric body feel.

1V-LSD produces no physical dependence, and LSD — its active metabolite — has no established lethal dose in humans.[2] The primary risk is psychological: high doses can trigger acute panic or psychotic breakdown, and the danger scales with dose and personal vulnerability.[1]

Dose and durationby route · individual sensitivity varies

Oral(µg)
Threshold< 15 µgLight25 – 75 µgCommon75 – 150 µgStrong150 – 300 µgHeavy300+ µg

Starts in 20 – 60 minLasts 8 – 12 hoursAfter-effects 6 – 24 hours

Body and dependence

Acute toxicity
Negligible
Chronic toxicity
Negligible
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
LSD; psilocybin; mescaline; DMT; 2C-B

Effectslikely at a common dose

Perception
Auditory enhancement; Color enhancement; Visual drifting; Color alteration; Music enhancement; Environmental patterning; Geometry; Holotropic state; Visual breathing; +29 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
Body
Wakefulness; Stimulation; Spontaneous body sensations; Pupil dilation; Body high; Body scan awareness; Insomnia; +27 possible, including Muscle tension, Heart rate perception changes, Excessive sweating
Thinking
Conceptual thinking; Novelty enhancement; Aesthetic enhancement; Cognitive flexibility; Introspection enhancement; Openness enhancement; Thought connectivity; +28 possible, including Suggestibility enhancement, Memory suppression, Thought loops
Feeling
Emotional enhancement; Emotional lability; +8 possible, including Anxiety, Paranoia, Dysphoria
Self
none likely · 12 possible, including Derealization, Depersonalization, Ego inflation
Time
Time alteration; +4 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
Personal insight; +7 possible

Who shouldn't take it

Absolute
Psychotic disorders; Pregnancy; Lithium use
Relative
Severe cardiovascular disease; Epilepsy; Bipolar disorder

Combinations60 recorded

Lethal (1)
MAOIs
Dangerous (19)
MDMA, MDA; Buspirone; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); NRIs; NSAIDs; Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (36)
See full page: psychedex.org/substances/1v-lsd
Not graded (4)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^abHolze F, Vizeli P, Müller F, Ley L, Duerig R, Varghese N, Zizzari P, Liechti ME (2021) Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects — Neuropsychopharmacology doi:10.1038/s41386-020-00883-6
  2. [2]
    ^Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A (2008) The pharmacology of lysergic acid diethylamide: a review — CNS Neuroscience and Therapeutics doi:10.1111/j.1755-5949.2008.00059.x
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