1P-ETH-LAD Facts
Psychedelic;
Description
1P-ETH-LAD (1-propionyl-N⁶-ethyl-6-norlysergic acid diethylamide) is a synthetic psychedelic of the lysergamide class. It activates serotonin receptors in the brain, producing the visual and cognitive distortions characteristic of classical psychedelics.
Subjective effects include geometric visual patterns, color enhancement, time alteration, and sharp analytical thinking. The experience is cerebral and visually intense — colder and more analytical than LSD, with less emotional warmth.
1P-ETH-LAD does not produce physical dependence, and tolerance builds so rapidly after a single dose that compulsive redosing becomes self-limiting.[1] The dominant risk is psychological — difficult experiences scale with dose, and a rare but documented condition of lasting visual disturbances can follow even a single use.
Dose and durationby route · individual sensitivity varies
Starts in 30 – 90 minLasts 6 – 12 hoursAfter-effects 6 – 24 hours
Body and dependence
- Acute toxicity
- Negligible
- Chronic toxicity
- Negligible
- Physical dependence
- None
- Psychological dependence
- Negligible
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 7 days
- Carries over to
- LSD;
psilocybin; mescaline; DMT; AL-LAD; 1P-LSD; 1B-LSD; 1CP-LSD
Effectslikely at a common dose
- Perception
- Tracers;
After-images; Environmental patterning; Geometry; Visual breathing; Visual morphing; Color enhancement; Visual drifting; Color alteration; Music enhancement; +21 possible, including Vestibular distortion, Spatial disorientation, Visual haze / noise - Body
- Stimulation;
Pupil dilation; Wakefulness; Body high; Insomnia; +25 possible, including Heart rate perception changes, Nausea, Muscle tension - Thinking
- Pattern recognition enhancement;
Conceptual thinking; Immersion enhancement; Novelty enhancement; Aesthetic enhancement; Introspection enhancement; Thought connectivity; +24 possible, including Thought loops, Suggestibility enhancement, Memory suppression - Feeling
- Emotional enhancement;
Emotional lability; +7 possible, including Anxiety, Paranoia, Dysphoria - Self
- none likely · 9 possible, including Derealization, Depersonalization
- Time
- Time alteration;
+4 possible, including Temporal disorientation - Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 5 possible
Who shouldn't take it
Combinations60 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, et al. (2023) Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential — Nature Communications doi:10.1038/s41467-023-44016-1