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1cP-MiPLA Facts

Psychedelic; Lysergamide; Serotonin 2A receptor agonist

Description

1cP-MiPLA (1-cyclopropanoyl-N-methyl-N-isopropyllysergamide) is a synthetic psychedelic of the lysergamide class. The body converts it into MiPLA, which activates serotonin receptors in the brain, producing the visual and cognitive shifts characteristic of classical psychedelics.

Subjective effects include geometric visual patterns, brightened colors, time alteration, thought acceleration, and emotional enhancement. The experience resembles a lighter, shorter version of LSD — qualitatively the same classical psychedelic character but less intense, reflecting MiPLA's weaker serotonin receptor binding.[1]

1cP-MiPLA produces no physical dependence, and acute toxicity is expected to be negligible, by analogy with LSD.[2] The primary risks are psychological — panic, paranoia, and rare persistent visual disturbances after the drug wears off[3] — and combining it with MAOIs or tramadol can trigger dangerous serotonin overload.[4]

Dose and durationby route · individual sensitivity varies

Oral(µg)
Threshold< 50 µgLight100 – 150 µgCommon150 – 200 µgStrong200 – 250 µgHeavy300+ µg

Starts in 20 – 40 minLasts 4 – 6 hoursAfter-effects 2 – 6 hours

Body and dependence

Acute toxicity
Negligible
Chronic toxicity
Negligible
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
LSD; psilocybin; mescaline; DOI

Effectslikely at a common dose

Perception
Color enhancement; Music enhancement; Geometry; Visual breathing; +31 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
Body
Pupil dilation; Body scan awareness; +28 possible, including Nausea, Dizziness, Heart rate perception changes
Thinking
Introspection enhancement; Openness enhancement; +31 possible, including Thought loops, Memory suppression, Cognitive impairment
Feeling
none likely · 9 possible, including Emotional lability, Anxiety, Paranoia
Self
none likely · 10 possible, including Depersonalization, Derealization
Time
none likely · 3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 7 possible

Who shouldn't take it

Absolute
Personal or family history of psychosis or schizophrenia spectrum disorders; Bipolar disorder; Pregnancy; Concurrent tramadol use; Concurrent MAOI use
Relative
Cardiovascular disease; Concurrent lithium use

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (18)
MDMA, MDA; NRIs; Buspirone; Dopamine agonists; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (38)
See full page: psychedex.org/substances/1cp-mipla
Not graded (4)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Huang X, Marona-Lewicka D, Pfaff RC, Nichols DE (1994) Drug discrimination and receptor binding studies of N-isopropyl lysergamide derivatives — Pharmacology, Biochemistry, and Behavior PMID:8208787
  2. [2]
    ^Nichols DE, Grob CS (2018) Is LSD toxic? — Forensic Science International doi:10.1016/j.forsciint.2018.01.006
  3. [3]
    ^Martinotti G, Santacroce R, Pettorruso M, Montemitro C, Spano MC, Lorusso M, Di Giannantonio M, Gallimberti L (2018) Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives — Brain Sciences doi:10.3390/brainsci8030047
  4. [4]
    ^Rached G, Campana A, Fiani D, et al. (2026) Safety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances — CNS Drugs doi:10.1007/s40263-025-01256-7
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