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1B-LSD Facts

Psychedelic; Lysergamide; Serotonin 2A receptor agonist

Description

1B-LSD (1-butanoyl-lysergic acid diethylamide) is a synthetic psychedelic of the lysergamide class. It activates serotonin receptors in the brain,[1] producing the perceptual and cognitive shifts characteristic of classical psychedelics.

Subjective effects include geometric visual patterns, color enhancement, time alteration, thought acceleration, and ego dissolution. The experience is widely reported as indistinguishable from LSD — long, analytically sharp, with a buzzing physical stimulation unlike the sedation typical of other psychedelics.

1B-LSD does not produce physical dependence, and the active compound LSD has no established lethal dose in humans.[2] The primary danger is psychological: acute panic and destabilizing ego dissolution scale with dose[3] and pre-existing anxiety.[4]

Dose and durationby route · individual sensitivity varies

Oral(µg)
Threshold< 15 µgLight25 – 75 µgCommon75 – 150 µgStrong150 – 300 µgHeavy300+ µg

Starts in 20 – 60 minLasts 8 – 12 hoursAfter-effects 6 – 24 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
LSD; psilocybin; mescaline; DMT; DOI; 1P-LSD; ALD-52; 1CP-LSD

Effectslikely at a common dose

Perception
Music enhancement; Auditory enhancement; Color enhancement; Visual drifting; Color alteration; Depth perception distortion; Tracers; Geometry; Holotropic state; Visual breathing; +28 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
Body
Wakefulness; Stimulation; Spontaneous body sensations; Appetite suppression; Pupil dilation; Body scan awareness; Insomnia; +33 possible, including Heart rate perception changes, Muscle tension, Vasoconstriction
Thinking
Conceptual thinking; Novelty enhancement; Pattern recognition enhancement; Aesthetic enhancement; Introspection enhancement; Openness enhancement; Thought connectivity; +30 possible, including Suggestibility enhancement, Memory suppression, Thought disorganization
Feeling
Emotional enhancement; +8 possible, including Emotional lability, Anxiety, Dysphoria
Self
none likely · 14 possible, including Derealization, Depersonalization, Ego inflation
Time
Time alteration; +4 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 7 possible

Who shouldn't take it

Absolute
Psychotic disorders; Pregnancy; Concurrent lithium use; Concurrent tramadol use
Relative
Severe cardiovascular disease; Epilepsy; Bipolar disorder; CYP2D6 poor metabolizer status

Combinations60 recorded

Lethal (1)
MAOIs
Dangerous (19)
MDMA, MDA; Buspirone; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); NRIs; NSAIDs; Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (36)
See full page: psychedex.org/substances/1b-lsd
Not graded (4)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD (2020) Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD) — Neuropharmacology doi:10.1016/j.neuropharm.2019.107856
  2. [2]
    ^Nichols DE (2016) Psychedelics — Pharmacological Reviews doi:10.1124/pr.115.011478
  3. [3]
    ^Holze F, Vizeli P, Müller F, Ley L, Duerig R, Varghese N, Zizzari P, Liechti ME (2021) Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects — Neuropsychopharmacology doi:10.1038/s41386-020-00883-6
  4. [4]
    ^Vizeli P, Studerus E, Holze F, Schmid Y, Dolder PC, Ley L, Straumann I, Becker AM, Müller F, Arikci D, Liechti ME (2024) Pharmacological and non-pharmacological predictors of the LSD experience in healthy participants — Translational Psychiatry doi:10.1038/s41398-024-03074-9
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